Therapeutic potential of short-chain fatty acid production by gut microbiota in neurodegenerative disorders

S Yadav, A Dwivedi, A Tripathi, AK Tripathi - Nutrition Research, 2022 - Elsevier
Dietary fibers are a major source of short-chain fatty acids (SCFAs) in the body, and the
fermentation products of SCFAs induced by intestinal microbiota affect energy metabolism …

Gut microbiota-derived short chain fatty acids act as mediators of the gut–brain axis targeting age-related neurodegenerative disorders: a narrative review

B Guo, J Zhang, W Zhang, F Chen… - Critical Reviews in Food …, 2023 - Taylor & Francis
Neurodegenerative diseases associated with aging are often accompanied by cognitive
decline and gut microbiota disorder. But the impact of gut microbiota on these cognitive …

[HTML][HTML] Mechanisms of short-chain fatty acids derived from gut microbiota in Alzheimer's disease

X Qian, R Xie, X Liu, H Tang - Aging and disease, 2022 - ncbi.nlm.nih.gov
Short-chain fatty acids (SCFAs) are important metabolites derived from the gut microbiota
through fermentation of dietary fiber. SCFAs participate a number of physiological and …

[HTML][HTML] Role of microbiota-derived short-chain fatty acids in nervous system disorders

R Mirzaei, B Bouzari, SR Hosseini-Fard… - Biomedicine & …, 2021 - Elsevier
During the past decade, accumulating evidence from the research highlights the suggested
effects of bacterial communities of the human gut microbiota and their metabolites on health …

The regulatory roles of dietary fibers on host health via gut microbiota-derived short chain fatty acids

T Xu, X Wu, J Liu, J Sun, X Wang, G Fan… - Current Opinion in …, 2022 - Elsevier
As a component of nutraceuticals, dietary fibers (DFs) are essential for maintain human
growth and health via the regulation of gut microbiota in the digestive tract. In this review, we …

Targeting gut dysbiosis and microbiome metabolites for the development of therapeutic modalities for neurological disorders

MD Wiefels, E Furar, RS Eshraghi… - Current …, 2024 - ingentaconnect.com
The gut microbiota, composed of numerous species of microbes, works in synergy with the
various organ systems in the body to bolster our overall health and well-being. The most …

The functional roles of short chain fatty acids as postbiotics in human gut: future perspectives

ML Ragavan, S Hemalatha - Food Science and Biotechnology, 2024 - Springer
The significance of gut microbiome and their metabolites (postbiotics) on human health
could be a promising approach to treat various diseases that includes inflammatory bowel …

Gut–brain axis as a pathological and therapeutic target for neurodegenerative disorders

ARL Toledo, GR Monroy, FE Salazar, JY Lee… - International journal of …, 2022 - mdpi.com
Human lifestyle and dietary behaviors contribute to disease onset and progression.
Neurodegenerative diseases (NDDs), considered multifactorial disorders, have been …

Role of microbial dysbiosis in the pathogenesis of Alzheimer's disease

G Susmitha, R Kumar - Neuropharmacology, 2023 - Elsevier
Alzheimer's disease (AD) is the leading cause of dementia in the elderly and detected
during the advanced stages where the chances of reversal are minimum. The gut-brain axis …

The role of short-chain fatty acids in microbiota–gut–brain cross-talk with a focus on amyotrophic lateral sclerosis: a systematic review

A Moțățăianu, G Șerban, S Andone - International Journal of Molecular …, 2023 - mdpi.com
Amyotrophic lateral sclerosis is a devastating neurodegenerative disease characterized by
the gradual loss of motor neurons in the brain and spinal cord, leading to progressive motor …