Diabetogenic T cells recognize insulin bound to IAg7 in an unexpected, weakly binding register
BD Stadinski, L Zhang, F Crawford… - Proceedings of the …, 2010 - National Acad Sciences
A peptide derived from the insulin B chain contains a major epitope for diabetogenic CD4+ T
cells in the NOD mouse model of type 1 diabetes (T1D). This peptide can fill the binding …
cells in the NOD mouse model of type 1 diabetes (T1D). This peptide can fill the binding …
Monoclonal antibody blocking the recognition of an insulin peptide–MHC complex modulates type 1 diabetes
L Zhang, F Crawford, L Yu, A Michels… - Proceedings of the …, 2014 - National Acad Sciences
The primary autoantigen triggering spontaneous type 1 diabetes mellitus in nonobese
diabetic (NOD) mice is insulin. The major T-cell insulin epitope lies within the amino acid 9 …
diabetic (NOD) mice is insulin. The major T-cell insulin epitope lies within the amino acid 9 …
Regulatory vs. inflammatory cytokine T-cell responses to mutated insulin peptides in healthy and type 1 diabetic subjects
M Nakayama, K McDaniel… - Proceedings of the …, 2015 - National Acad Sciences
Certain class II MHC (MHCII) alleles in mice and humans confer risk for or protection from
type 1 diabetes (T1D). Insulin is a major autoantigen in T1D, but how its peptides are …
type 1 diabetes (T1D). Insulin is a major autoantigen in T1D, but how its peptides are …
Position β57 of IAg7 controls early anti-insulin responses in NOD mice, linking an MHC susceptibility allele to type 1 diabetes onset
L Gioia, M Holt, A Costanzo, S Sharma, B Abe… - Science …, 2019 - science.org
The class II region of the major histocompatibility complex (MHC) locus is the main
contributor to the genetic susceptibility to type 1 diabetes (T1D). The loss of an aspartic acid …
contributor to the genetic susceptibility to type 1 diabetes (T1D). The loss of an aspartic acid …
Specificity and detection of insulin-reactive CD4+ T cells in type 1 diabetes in the nonobese diabetic (NOD) mouse
F Crawford, B Stadinski, N Jin… - Proceedings of the …, 2011 - National Acad Sciences
In the nonobese diabetic (NOD) mouse model of type 1 diabetes (T1D), an insulin peptide
(B: 9–23) is a major target for pathogenic CD4+ T cells. However, there is no consensus on …
(B: 9–23) is a major target for pathogenic CD4+ T cells. However, there is no consensus on …
Ex vivo analysis of thymic CD4 T cells in nonobese diabetic mice with tetramers generated from I-Ag7/class II-associated invariant chain peptide precursors
MH Jang, NP Seth… - The Journal of Immunology, 2003 - journals.aai.org
The MHC determines susceptibility and resistance to type 1 diabetes in humans and
nonobese diabetic (NOD) mice. To investigate how a disease-associated MHC molecule …
nonobese diabetic (NOD) mice. To investigate how a disease-associated MHC molecule …
Autoreactive T cells specific for insulin B: 11-23 recognize a low-affinity peptide register in human subjects with autoimmune diabetes
J Yang, IT Chow, T Sosinowski… - Proceedings of the …, 2014 - National Acad Sciences
Previous studies in type 1 diabetes (T1D) in the nonobese diabetic mouse demonstrated
that a crucial insulin epitope (B: 9-23) is presented to diabetogenic CD4 T cells by IAg7 in a …
that a crucial insulin epitope (B: 9-23) is presented to diabetogenic CD4 T cells by IAg7 in a …
The A-chain of insulin is a hot-spot for CD4+ T cell epitopes in human type 1 diabetes
Summary Type 1 diabetes (T1D) is caused by T cell-mediated destruction of the pancreatic
insulin-producing β cells. While the role of CD4+ T cells in the pathogenesis of T1D is …
insulin-producing β cells. While the role of CD4+ T cells in the pathogenesis of T1D is …
Register shifting of an insulin peptide–MHC complex allows diabetogenic T cells to escape thymic deletion
JF Mohan, SJ Petzold, ER Unanue - Journal of Experimental Medicine, 2011 - rupress.org
In nonobese diabetic (NOD) mice, two sets of autoreactive CD4+ T cells recognize the B: 9–
23 segment of the insulin B chain. One set, type A, recognizes insulin presented by antigen …
23 segment of the insulin B chain. One set, type A, recognizes insulin presented by antigen …
The diabetogenic mouse MHC class II molecule IAg7 is endowed with a switch that modulates TCR affinity
K Yoshida, AL Corper, R Herro, B Jabri… - The Journal of …, 2010 - Am Soc Clin Investig
Genetic susceptibility to autoimmunity is frequently associated with specific MHC alleles.
Diabetogenic MHC class II molecules, such as human HLA-DQ8 and mouse I-Ag7, typically …
Diabetogenic MHC class II molecules, such as human HLA-DQ8 and mouse I-Ag7, typically …