Previous studies have shown that CCL2 may cause chronic pain, but the exact mechanism
of central sensitization is unclear. In this article, we further explore the presynaptic role of …

Mounting evidence supports an important role of chemokines, produced by spinal cord
astrocytes, in promoting central sensitization and chronic pain. In particular, CCL2 (C–C …

Previous studies have shown that CCL2 (C–C motif chemokine ligand 2) induces chronic
pain, but the exact mechanisms are still unknown. Here, we established models to explore …

Background: The CCR2/CCL2 system has been identified as a regulator in the
pathogenesis of neuropathy-induced pain. However, CCR2 target validation in analgesia …

A better understanding of the mechanisms linked to chemokine pronociceptive effects is
essential for the development of new strategies to better prevent and treat chronic pain …

Cytokines such as interleukins are known to be involved in the development of neuropathic
pain through activation of neuroglia. However, the role of chemokine (CC motif) ligand 1 …

The anterior cingulate cortex (ACC) is activated by noxious stimuli and is involved in the
affective component of pain processing; but its role in the sensory component of pain …

CCL2 chemokine and its receptor CCR2 may contribute to neuropathic pain development.
We tested the hypothesis that injury to peripheral nerves triggers CCL2 release from …

Background Previous studies have demonstrated that the CXCL12/CXCR4 signaling axis is
involved in the regulation of neuropathic pain (NP). Here, we performed experiments to test …

Lumbar disc herniation (LDH) is a major cause of sciatica, but the underlying mechanisms
are not well understood. Chemokine CCL2 has been implicated to play a vital role in the …