Im Rahmen eines Industrieprojektes der Firma Beiersdorf wurde in enger Kooperation mit
den Arbeitskreisen von Prof. Klebe und Prof. Röhm die Synthese neuartiger Inhibitoren der …

Die Entwicklung von Farnesyltransferase-Inhibitoren als Malariatherapeutika wird dadurch
erschwert, dass die heterologe Expression der Farnesyltransferase von P. falciparum bisher …

The development of antimalarial agents is not only constricted by the parameters common to
the development of all new drugs (efficacy, toxicity, pharmacology), but importantly, must …

Farnesyltransferase catalyzes the posttranslational modification of numerous proteins
involved in intracellular signal transduction by transferring the farnesyl residue of farnesyl …

Introduction: Tyrosinase is responsible for melanin production. The overproduction of
melanin causes many skin disorders. The inhibition of tyrosinase activity would appear to be …

The development of farnesyltransferase inhibitors directed against Plasmodium falciparum
is a strategy towards new drugs against malaria. Previously, we described benzophenone …

Water solubility was previously found to be essential for in vivo-antimalarial activity of a
novel type of benzophenone-based farnesyltransferase inhibitors. Introduction of a α-amino …

We report a series of novel inhibitors of protein farnesyltransferase based on the 2-
oxotetrahydroquinoline scaffold. We developed an efficient synthesis of these compounds …

Farnesyltransferase catalyzing the transfer of a farnesyl residue from farnesylpyrophosphate
to the thiol of a cysteine side chain of proteins carrying the C-terminal CAAX-tetrapeptide …

The enzyme tyrosinase is known to be a multifunctional copper-containing enzyme from the
oxidase superfamily, which is the key protein involved in the biosynthesis of the large …