Micro and Nanoparticles as Carriers for Streptokinase: A Mini-Review on Efficacy, Side Effects and Pharmacokinetics
A Amani - Nanomedicine Research Journal, 2024 - nanomedicine-rj.com
Streptokinase is being successfully used as a thrombolytic agent for restoring the blood flow
following thromboembolism and myocardial infarction. However, high immunogenicity of the …
following thromboembolism and myocardial infarction. However, high immunogenicity of the …
Use of mPEG-PLGA nanoparticles to improve bioactivity and hemocompatibility of streptokinase: In-vitro and in-vivo studies
A Hasanpour, F Esmaeili, H Hosseini… - Materials Science and …, 2021 - Elsevier
Streptokinase, a clot-dissolving agent, is widely used in treatment of cardiovascular
diseases such as blood clots and deep thrombosis. Streptokinase is a cost-effective drug …
diseases such as blood clots and deep thrombosis. Streptokinase is a cost-effective drug …
Liposomes for the delivery of streptokinase
Streptokinase is an efficient thrombolytic agent used to treat thromboembolic disorders.
Conventional streptokinase formulations have limited thrombolytic activity and several …
Conventional streptokinase formulations have limited thrombolytic activity and several …
Preparation of PEG-grafted chitosan/streptokinase nanoparticles to improve biological half-life and reduce immunogenicity of the enzyme
Streptokinase, as a thrombolytic drug, is widely used in treatment of cardiovascular
disorders and deep vein thrombosis. Streptokinase is immunogenic due to its prokaryotic …
disorders and deep vein thrombosis. Streptokinase is immunogenic due to its prokaryotic …
Comparative effects of PEG-containing liposomal formulations on in vivo pharmacokinetics of streptokinase
SE Jin, IS Kim, CK Kim - Archives of pharmacal research, 2015 - Springer
Streptokinase (SK) is an effective thrombolytic agent, but it has a short half-life due to its
rapid elimination from the body. In this study, we prepared and evaluated polyethyleneglycol …
rapid elimination from the body. In this study, we prepared and evaluated polyethyleneglycol …
Development and characterization of highly selective target-sensitive liposomes for the delivery of streptokinase: in vitro/in vivo studies
Streptokinase is one of the most commonly used thrombolytic agents for the treatment of
thromboembolism. Short half-life of the streptokinase requires administration of higher dose …
thromboembolism. Short half-life of the streptokinase requires administration of higher dose …
Optimization of self-assembled chitosan/streptokinase nanoparticles and evaluation of their cytotoxicity and thrombolytic activity
H Baharifar, G Tavoosidana, R Karimi… - … of nanoscience and …, 2015 - ingentaconnect.com
In this study, the enzyme streptokinase (thrombolysis agent) and chitosan (Cs) nanoparticles
were prepared by self-assembly. Using experimental design, chitosan concentration …
were prepared by self-assembly. Using experimental design, chitosan concentration …
On-chip preparation of streptokinase entrapped in chitosan nanoparticles used in thrombolytic therapy potentially
M Shamsi, P Zahedi - Journal of pharmaceutical sciences, 2017 - Elsevier
The objective of this work was to prepare the streptokinase (SK) entrapped in chitosan
nanoparticles (CS NPs) using bulk mixing (BM) and microfluidic (MF) techniques. The …
nanoparticles (CS NPs) using bulk mixing (BM) and microfluidic (MF) techniques. The …
Streptokinase loading in liposomes for vascular targeted nanomedicine applications: encapsulation efficiency and effects of processing
B Holt, AS Gupta - Journal of Biomaterials Applications, 2012 - journals.sagepub.com
Vascular diseases leading to thrombo-occlusion are the leading cause of morbidity and
mortality worldwide. Revascularization and restoration of antegrade blood flow is critical for …
mortality worldwide. Revascularization and restoration of antegrade blood flow is critical for …
Efficiency of targeted delivery of streptokinase based on fibrin-specific liposomes in the in vivo experiment
A Igor, V Tatyana, L Irina, D Katsiaryna… - Drug Delivery and …, 2023 - Springer
Acute thrombosis has a narrow therapeutic window and remains the leading cause of
morbidity and mortality, while thrombolytic therapy has limited efficacy and risk of side …
morbidity and mortality, while thrombolytic therapy has limited efficacy and risk of side …