The role of changes in the extracellular potassium concentration [K+] o in epilepsy has
remained unclear. Historically, it was hypothesized that [K+] o is the causal factor for …

Potassium channels dysfunction and altered genes encoding for molecules involved in
potassium homeostasis have been associated with human epilepsy. These observations are …

Changes in membrane voltage brought about by ion fluxes through voltage and transmitter-
gated channels represent the basis of neural activity. As such, electrochemical gradients …

Glial cells are believed to play a major role in the regulation of the extracellular potassium
concentration ([K+] o), particularly when the [K+] o is increased. Using ion‐selective …

Ions in the brain are regulated independently from plasma levels by active transport across
choroid plexus epithelium and cerebral capillary endothelium, assisted by astrocytes. In …

Ionic concentrations fluctuate significantly during epileptic seizures. In this study, using a
combination of in vitro electrophysiology, computer modeling, and dynamical systems …

Pharmacoresistant epilepsy is a chronic neurological condition in which a basal brain
hyperexcitability results in paroxysmal hypersynchronous neuronal discharges. Human …

An increase of extracellular potassium ion concentration can result in neuronal
hyperexcitability, and thus contribute to non-synaptic epileptiform activity. It has been shown …

This review attempts to give a concise and up-to-date overview on the role of potassium
channels in epilepsies. Their role can be defined from a genetic perspective, focusing on …

Epileptic seizures constitute a complex multiscale phenomenon that is characterized by
synchronized hyperexcitation of neurons in neuronal networks. Recent progress in …