ER-phagy: mechanisms, regulation, and diseases connected to the lysosomal clearance of the endoplasmic reticulum

F Reggiori, M Molinari - Physiological reviews, 2022 - journals.physiology.org
ER-phagy (reticulophagy) defines the degradation of portions of the endoplasmic reticulum
(ER) within lysosomes or vacuoles. It is part of the self-digestion (ie, autophagic) programs …

[HTML][HTML] Emerging principles of selective ER autophagy

S Wilkinson - Journal of molecular biology, 2020 - Elsevier
The endoplasmic reticulum (ER) is a fundamental organelle in cellular metabolism and
signal transduction. It is subject to complex, dynamic sculpting of morphology and …

ER-phagy, ER homeostasis, and ER quality control: implications for disease

S Ferro-Novick, F Reggiori, JL Brodsky - Trends in biochemical sciences, 2021 - cell.com
Lysosomal degradation of endoplasmic reticulum (ER) fragments by autophagy, termed ER-
phagy or reticulophagy, occurs under normal as well as stress conditions. The recent …

ER‐phagy: shaping up and destressing the endoplasmic reticulum

S Wilkinson - The FEBS journal, 2019 - Wiley Online Library
The endoplasmic reticulum (ER) network has central roles in metabolism and cellular
organization. The ER undergoes dynamic alterations in morphology, molecular composition …

ER-phagy: quality control and turnover of endoplasmic reticulum

H Chino, N Mizushima - Trends in Cell Biology, 2020 - cell.com
The endoplasmic reticulum (ER) is the largest organelle in cells and has fundamental
functions, such as folding, processing, and trafficking of proteins, cellular metabolism, and …

[HTML][HTML] Endoplasmic reticulum turnover: ER-phagy and other flavors in selective and non-selective ER clearance

I Fregno, M Molinari - F1000Research, 2018 - ncbi.nlm.nih.gov
The endoplasmic reticulum (ER) is a highly dynamic organelle in eukaryotic cells. It is
deputed to lipid and protein biosynthesis, calcium storage, and the detoxification of various …

ER-phagy mediates selective degradation of endoplasmic reticulum independently of the core autophagy machinery

S Schuck, CM Gallagher, P Walter - Journal of cell science, 2014 - journals.biologists.com
Selective autophagy of damaged or redundant organelles is an important mechanism for
maintaining cell homeostasis. We found previously that endoplasmic reticulum (ER) stress in …

ER-phagy at a glance

P Grumati, I Dikic, A Stolz - Journal of cell science, 2018 - journals.biologists.com
Selective autophagy represents the major quality control mechanism that ensures proper
turnover of exhausted or harmful organelles, among them the endoplasmic reticulum (ER) …

ER‐phagy: selective autophagy of the endoplasmic reticulum

K Mochida, H Nakatogawa - EMBO reports, 2022 - embopress.org
Eukaryotic cells adequately control the mass and functions of organelles in various
situations. Autophagy, an intracellular degradation system, largely contributes to this …

[PDF][PDF] ER remodeling via ER-phagy

A Gubas, I Dikic - Molecular Cell, 2022 - cell.com
The endoplasmic reticulum (ER) is a hotspot for many essential cellular functions. The ER
membrane is highly dynamic, which affects many cellular processes that take place within …