Enhancement of autophagic flux after neonatal cerebral hypoxia-ischemia and its region-specific relationship to apoptotic mechanisms

V Ginet, J Puyal, PGH Clarke, AC Truttmann - The American journal of …, 2009 - Elsevier
The multiplicity of cell death mechanisms induced by neonatal hypoxia-ischemia makes
neuroprotective treatment against neonatal asphyxia more difficult to achieve. Whereas the …

Autophagy in hypoxia-ischemia induced brain injury: evidences and speculations

W Balduini, S Carloni, G Buonocore - Autophagy, 2009 - Taylor & Francis
The interaction among autophagy, apoptosis and necrosis is complex and still a matter of
debate. We have recently studied this interaction after neonatal hypoxia-ischemia (HI) in …

Neuronal death after perinatal cerebral hypoxia-ischemia: Focus on autophagy—mediated cell death

C Descloux, V Ginet, PGH Clarke, J Puyal… - International Journal of …, 2015 - Elsevier
Neonatal hypoxic-ischemic encephalopathy is a critical cerebral event occurring around
birth with high mortality and neurological morbidity associated with long-term invalidating …

Protective role of autophagy in neonatal hypoxia–ischemia induced brain injury

S Carloni, G Buonocore, W Balduini - Neurobiology of disease, 2008 - Elsevier
Autophagy, an intracellular bulk degradation process of cellular constituents, plays a key
role in cell homeostasis and can be induced by stresses, such as nutrient depletion, closed …

[HTML][HTML] Impaired autophagosome clearance contributes to neuronal death in a piglet model of neonatal hypoxic-ischemic encephalopathy

D Cui, D Sun, X Wang, L Yi, E Kulikowicz… - Cell death & …, 2017 - nature.com
To examine the temporal relationship of cortical autophagic flux with delayed neuronal cell
death after hypoxia-ischemia (HI) in neonatal piglets. HI was produced with 45-min hypoxia …

Targeting autophagy to prevent neonatal stroke damage

J Puyal, PGH Clarke - Autophagy, 2009 - Taylor & Francis
Cell death due to cerebral ischemia has been attributed to necrosis and apoptosis, but
autophagic mechanisms have recently been implicated as well. Using rats exposed to …

Dying neurons in thalamus of asphyxiated term newborns and rats are autophagic

V Ginet, MP Pittet, C Rummel, MC Osterheld… - Annals of …, 2014 - Wiley Online Library
Objective Neonatal hypoxic–ischemic encephalopathy (HIE) still carries a high burden by its
mortality and long‐term neurological morbidity in survivors. Apart from hypothermia, there is …

Postischemic treatment of neonatal cerebral ischemia should target autophagy

J Puyal, A Vaslin, V Mottier… - Annals of Neurology …, 2009 - Wiley Online Library
Objective To evaluate the contributions of autophagic, necrotic, and apoptotic cell death
mechanisms after neonatal cerebral ischemia and hence define the most appropriate …

Excessive autophagy contributes to neuron death in cerebral ischemia

R Shi, J Weng, L Zhao, XM Li, TM Gao… - CNS neuroscience & …, 2012 - Wiley Online Library
Aims: To determine the extent to which autophagy contributes to neuronal death in cerebral
hypoxia and ischemia. Methods: We performed immunocytochemistry, western blot, cell …

Eaten alive: autophagy and neuronal cell death after hypoxia-ischemia

CT Chu - The American journal of pathology, 2008 - Elsevier
Eaten Alive: Autophagy and Neuronal Cell Death after Hypoxia-Ischemia - ScienceDirect
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