[HTML][HTML] Pathogenic mechanisms associated with different clinical courses of multiple sclerosis

H Lassmann - Frontiers in immunology, 2019 - frontiersin.org
In the majority of patients multiple sclerosis starts with a relapsing remitting course (RRMS),
which may at later times transform into secondary progressive disease (SPMS). In a minority …

Update on inflammation, neurodegeneration, and immunoregulation in multiple sclerosis: therapeutic implications

JL Bennett, O Stüve - Clinical neuropharmacology, 2009 - journals.lww.com
Multiple sclerosis (MS) is an inflammatory, demyelinating, and neurodegenerative disease
of the central nervous system of uncertain etiology. There is consensus that a dysregulated …

[HTML][HTML] Contribution of CD8 T lymphocytes to the immuno-pathogenesis of multiple sclerosis and its animal models

LT Mars, P Saikali, RS Liblau, N Arbour - Biochimica et Biophysica Acta …, 2011 - Elsevier
Multiple sclerosis (MS) is an inflammatory disease of the central nervous system (CNS)
characterized by multi-focal demyelination, axonal loss, and immune cell infiltration …

The immunopathophysiology of multiple sclerosis

GF Wu, E Alvarez - Neurologic clinics, 2011 - neurologic.theclinics.com
The cause of multiple sclerosis (MS) is elusive. However, clues to the pathogenesis of this
condition have traditionally been derived from the basic pathologic characterization of the …

Cytokines and immunity in multiple sclerosis: the dual signal hypothesis

G Martino, R Furlan, E Brambilla, A Bergami… - Journal of …, 2000 - Elsevier
Multiple sclerosis (MS) is considered an immune-mediated disease of the central nervous
system (CNS) sustained by a chronic inflammatory process leading to patchy demyelination …

Multiple sclerosis and T lymphocytes: an entangled story

L Legroux, N Arbour - Journal of Neuroimmune Pharmacology, 2015 - Springer
Multiple sclerosis (MS) is the prototypic inflammatory disease of the central nervous system
(CNS) characterized by multifocal areas of demyelination, axonal damage, activation of glial …

Pathology of multiple sclerosis

M Kipp, P van der Valk, S Amor - CNS & Neurological …, 2012 - ingentaconnect.com
Pathological examination of the affected human tissue is key to understanding the possible
mechanisms operating in the disease. In multiple sclerosis (MS), studies of central nervous …

New concepts in the immunopathogenesis of multiple sclerosis

B Hemmer, JJ Archelos, HP Hartung - Nature Reviews Neuroscience, 2002 - nature.com
Multiple sclerosis (MS) is a commonly occurring inflammatory and demyelinating
neurological disease. It has been considered to be an autoimmune disorder mediated by …

The neuroimmunology of multiple sclerosis: possible roles of T and B lymphocytes in immunopathogenesis

KC O'connor, A Bar-Or, DA Hafler - Journal of clinical immunology, 2001 - Springer
Multiple sclerosis (MS) is an inflammatory disease of the central nervous system white
matter. The association of the disease with MHC genes, the inflammatory white matter …

The immune response in multiple sclerosis

S Rodríguez Murúa, MF Farez… - Annual Review of …, 2022 - annualreviews.org
Multiple sclerosis (MS) is a chronic autoimmune, inflammatory, and neurodegenerative
disease that affects the central nervous system (CNS). MS is characterized by immune …