[HTML][HTML] From bench to bedside: The mGluR5 system in people with and without Autism Spectrum Disorder and animal model systems
C Carey, N Singh, JT Dunn, T Sementa… - Translational …, 2022 - nature.com
The metabotropic glutamate receptor 5 (mGluR5) is a key regulator of excitatory (E)
glutamate and inhibitory (I) γ-amino butyric acid (GABA) signalling in the brain. Despite the …
glutamate and inhibitory (I) γ-amino butyric acid (GABA) signalling in the brain. Despite the …
[HTML][HTML] Brain mGluR5 in Shank3B−/− Mice Studied With in vivo [18F]FPEB PET Imaging and ex vivo Immunoblotting
G Cai, M Wang, S Wang, Y Liu, Y Zhao, Y Zhu… - Frontiers in …, 2019 - frontiersin.org
Although several studies have found that metabotropic glutamate 5 receptor (mGluR5) may
play an important role in autism spectrum disorders (ASD), the mechanisms remain unclear …
play an important role in autism spectrum disorders (ASD), the mechanisms remain unclear …
[HTML][HTML] Cerebral expression of metabotropic glutamate receptor subtype 5 in idiopathic autism spectrum disorder and fragile X syndrome: a pilot study
Multiple lines of evidence suggest that dysfunction of the metabotropic glutamate receptor
subtype 5 (mGluR5) plays a role in the pathogenesis of autism spectrum disorder (ASD). Yet …
subtype 5 (mGluR5) plays a role in the pathogenesis of autism spectrum disorder (ASD). Yet …
[HTML][HTML] Metabotropic glutamate receptor 5 tracer [18F]-FPEB displays increased binding potential in postcentral gyrus and cerebellum of male individuals with autism …
Background Autism is a neurodevelopmental disorder that is first manifested during early
childhood. Postmortem experiments have identified significantly elevated expression of …
childhood. Postmortem experiments have identified significantly elevated expression of …
Decreased expression of mGluR5 within the dorsolateral prefrontal cortex in autism and increased microglial number in mGluR5 knockout mice: Pathophysiological …
Abstract Metabotropic glutamate receptor 5 (mGluR5) and microglial abnormalities have
been implicated in autism spectrum disorder (ASD). However, controversy exists as to …
been implicated in autism spectrum disorder (ASD). However, controversy exists as to …
[HTML][HTML] Overexpression of mGluR7 in the prefrontal cortex attenuates autistic behaviors in mice
X Wang, C Gao, Y Zhang, S Hu, Y Qiao… - Frontiers in cellular …, 2021 - frontiersin.org
Autism spectrum disorder (ASD) is associated with a range of abnormalities pertaining to
socialization, communication, repetitive behaviors, and restricted interests. Owing to its …
socialization, communication, repetitive behaviors, and restricted interests. Owing to its …
Glutamatergic synapse in autism: a complex story for a complex disorder
L Galineau, N Arlicot, AC Dupont, F Briend… - Molecular …, 2023 - nature.com
Autism spectrum disorder (ASD) is a neurodevelopmental disorder whose
pathophysiological mechanisms are still unclear. Hypotheses suggest a role for glutamate …
pathophysiological mechanisms are still unclear. Hypotheses suggest a role for glutamate …
Convergent evidence for mGluR5 in synaptic and neuroinflammatory pathways implicated in ASD
Abstract The pathogenesis of Autism Spectrum Disorder (ASD), a serious
neurodevelopmental disorder, is poorly understood. We review evidence for alterations in …
neurodevelopmental disorder, is poorly understood. We review evidence for alterations in …
[HTML][HTML] The evolutionary expansion of mGluR3-NAAG-GCPII signaling: relevance to human intelligence and cognitive disorders
AFT Arnsten, M Wang - American Journal of Psychiatry, 2020 - Am Psychiatric Assoc
In this issue of the Journal, Zink et al.(1) report remarkable new findings relating variance in
the folate hydrolase 1 (FOLH1) gene encoding for glutamate carboxypeptidase II (GCPII) to …
the folate hydrolase 1 (FOLH1) gene encoding for glutamate carboxypeptidase II (GCPII) to …
Negative allosteric modulation of the mGluR5 receptor reduces repetitive behaviors and rescues social deficits in mouse models of autism
JL Silverman, DG Smith, SJS Rizzo… - Science translational …, 2012 - science.org
Neurodevelopmental disorders such as autism and fragile X syndrome were long thought to
be medically untreatable, on the assumption that brain dysfunctions were immutably …
be medically untreatable, on the assumption that brain dysfunctions were immutably …