Acute myocardial infarction (MI) is a major cause of mortality and disability worldwide. In
patients with MI, the treatment option for reducing acute myocardial ischemic injury and …

Melatonin, the chief secretory product of the pineal gland, has been shown to protect the
heart against ischemia–reperfusion injury. This was attributed to its free radical scavenging …

This brief review summarizes the recently obtained evidence which illustrates the beneficial
effects of the endogenously produced antioxidant, melatonin, in reducing tissue damage …

Cardiac tissue loss is one of the most important factors leading to the unsatisfactory recovery
even after treatment of ischemic heart disease. Melatonin, a circadian molecule with marked …

Melatonin has potent cardioprotective properties. These actions have been attributed to its
free radical scavenging and anti‐oxidant actions, but may also be receptor mediated …

Melatonin is a pleiotropic, indole secreted, and synthesized by the human pineal gland.
Melatonin has biological effects including anti-apoptosis, protecting mitochondria, anti …

The production of oxygen free radicals has been strongly implicated as an important
pathophysiological mechanism mediating myocardial ischemia/reperfusion (I/R) injury …

There has been increased interest in melatonin recently, since it was shown to be a potent
scavenger of toxic free radicals. Melatonin has been found to be effective in protecting …

Melatonin is a pleiotropic hormone with several functions. It binds to specific receptors and
to a number of cytosolic proteins, activating a vast array of signalling pathways. Its potential …

BACKGROUND: Experimental studies have documented the beneficial effects of the
endogenously produced antioxidant, melatonin, in reducing tissue damage and limiting …