Fibroblasts are the most abundant “non-cancerous” cells in tumors. However, it remains
largely unknown how these cancer-associated fibroblasts (CAFs) promote tumor growth and …

Fibroblast activation is an accompanying feature of solid tumor progression, resembling a
conserved host response to tissue damage. Cancer-associated fibroblasts (CAFs) comprise …

Metabolic coupling, between mitochondria in cancer cells and catabolism in stromal
fibroblasts, promotes tumor growth, recurrence, metastasis, and predicts anticancer drug …

Simple Summary Tumors are a complex ecosystem including not only cancer cells, but also
many distinct cell types of the tumor micro-environment. While the Warburg effect assessing …

Cancer cells are well-known for adapting their metabolism to maintain high proliferation
rates and survive in unfavorable environments with low oxygen and nutritional deficiency …

Tumor metabolism is characterized with up-regulated glucose uptake and glycolytic rate of
tumor cells as the source of ATP and tumors growth, and regulated by a poorly defined …

Redox balance is associated with the regulation of several cell signalling pathways and
functions. In fact, under physiological conditions, cells maintain a balance between oxidant …

It is notorious that cancer cells alter their metabolism to adjust to harsh environments of
hypoxia and nutritional starvation. Metabolic reprogramming most often occurs in the tumor …

Significance: Here, we review certain recent advances in oxidative stress and tumor
metabolism, which are related to understanding the contributions of the microenvironment in …

Cancer associated fibroblasts (CAFs) are the main stromal cell type of solid tumour
microenvironment and undergo an activation process associated with secretion of growth …