Background: Phosphoinositide 3-kinase (PI3Ks) is a member of intracellular lipid kinases
and involved in the regulation of cellular proliferation, differentiation and survival …

ABSTRACT PI3K/AKT/mTOR signaling pathway is one of the key dysregulated pathways in
different tumor types, including colorectal cancer (CRC). Activation of this pathway is shown …

In the last decade treatment for colorectal cancer (CRC) has evolved with the addition of
contemporary chemotherapy drugs and targeted therapies. Despite this progress, our drug …

Colorectal cancer (CRC) is one of the deadliest human malignancies worldwide. Several
molecular pathways have been demonstrated to be involved in the initiation and …

Survival times of patients with colorectal cancer (CRC) have increased over the past
decade, primarily as a result of treatment with combinations of conventional cytotoxic agents …

Cancer is a severe public health issue that is a leading cause of mortality globally. It is also
an impediment to improving life expectancy worldwide. Furthermore, the global burden of …

Abstract Phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR)
signaling pathway is one of the major cellular signaling pathways that plays an important …

Colorectal cancer (CRC) is a predominant malignancy worldwide, being the fourth most
common cause of mortality and morbidity. The CRC incidence in adolescents, young adults …

Purpose To examine the in vitro and in vivo efficacy of the dual PI3K/mTOR inhibitor NVP-
BEZ235 in treatment of PIK3CA wild-type colorectal cancer (CRC). Experimental Design …

Zusammenfassung Die Phosphoinositol-3-OH-Kinase (PI3K) und die von ihr aktivierte
Serin/Threoninkinase Akt, auch als Proteinkinase B bekannt, sind wichtige Effektormoleküle …