Integrin αvβ3 has an important role in the proliferation, survival, invasion and migration of
vascular endothelial cells 1, 2. Like other integrins, αvβ3 can exist in different functional …

Formation of a stable lamellipodium at the front of migrating cells requires localization of Rac
activation to the leading edge. Restriction of α4 integrin phosphorylation to the leading edge …

Inflammatory recruitment of leukocytes is governed by dynamic interactions between
integrins and endothelial immunoglobulin superfamily (IgSF) proteins. We have identified …

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The movement of leukocytes from the blood into peripheral tissues plays a key role in
immunity as well as chronic inflammatory and autoimmune diseases. The shear force of …

Fig. 1 A role for integrin αvβ3 in governing survival of angiogenic endothelial cells. Data from
inhibitor studies and genetic investigations suggest that integrin αvβ3 (and likely other …

Upon binding to the extracellular matrix protein, fibronectin, αV-class and α5β1 integrins
trigger the recruitment of large protein assemblies and strengthen cell adhesion. Both …

Background: It has been postulated that the regulation of integrin vesicular traffic facilitates
cell migration by internalizing integrins at the rear of the cell and transporting them forward …

Integrins are heterodimeric cell-surface adhesion molecules comprising one of 18 possible
α-chains and one of eight possible β-chains. They control a range of cell functions in a …

Blood vessel formation requires endothelial cell interactions with the extracellular matrix
through cell surface receptors, and signaling events that control endothelial cell adhesion …