The human NatA protein N α-terminal-acetyltransferase complex is responsible for
cotranslational N-terminal acetylation of proteins with Ser, Ala, Thr, Gly, and Val N termini …

Co-translational N-terminal protein acetylation regulates many protein functions including
degradation, folding, interprotein interactions, and targeting. Human NatA (hNatA), one of six …

In eukaryotes, N-terminal acetylation is one of the most common protein modifications
involved in a wide range of biological processes. Most N-acetyltransferase complexes …

Huntington's disease (HD) is a neurodegenerative disorder caused by a poly-CAG
expansion in the first exon of the HTT gene, resulting in an extended poly-glutamine tract in …

Protein Nα-terminal acetylation (Nt-acetylation) is considered one of the most common
protein modification in eukaryotes, and 80-90% of all soluble human proteins are modified in …

Protein acetylation is a widespread modification that is mediated by site-selective
acetyltransferases. KATs (lysine N ϵ-acetyltransferases), modify the side chain of specific …

Huntington's disease is a polyglutamine expansion disorder, characterized by mutant HTT-
mediated aggregate formation and cytotoxicity. Many reports suggests roles of N-terminal 17 …

Expansion of polymorphic glutamine (Q) numbers present at the protein Huntingtin (Htt)
beyond 36Q results in its misfolding and aggregation, and the aggregates recruit several …

The human hARD1–NATH complex, cotranslationally acetylating the α-amino groups of
proteins, was recently described. In S. cerevisiae and D. melanogaster this NatA complex …

N-Terminal acetylation is a common and important protein modification catalyzed by N-
terminal acetyltransferases (NATs). Six human NATs (NatA–NatF) contain one catalytic …