A growing body of evidence demonstrates that fetal-derived tissue-resident macrophages
have developmental functions. It has been proposed that macrophages promote testicular …

In the testis, interstitial macrophages are thought to be derived from the yolk sac during fetal
development, and later replaced by bone marrow-derived macrophages. By contrast, the …

Testicular macrophages (tMφ) are the principal immune cells of the mammalian testis.
Beyond classical immune functions, they have been shown to be important for …

Organogenesis of the testis is initiated when expression of Sry in pre-Sertoli cells directs the
gonad toward a male-specific fate. The cells in the early bipotential gonad undergo de novo …

Macrophages are the principal immune cells of the epididymis and testis, but their origins,
heterogeneity, development, and maintenance are not well understood. Here, we describe …

Macrophages comprise a heterogeneous immune cell population and display niche-specific
phenotypes and functions in almost all organs. Testicular macrophages (TMs) perform …

Macrophages are innate immune cells present in essentially every organ of the body with
dedicated tissue specific functions. We will present in this review the unique properties and …

Testicular macrophages are the largest leukocyte population in the testis. Their environment
is characterized by the seemingly contradictory needs for tolerance against the …

The testis produces sperm throughout the male reproductive lifespan by balancing self-
renewal and differentiation of spermatogonial stem cells (SSCs). Part of the SSC niche is …

Spermatogenic cells express cell-specific molecules with the potential to be seen as
“foreign” by the immune system. Owing to the time difference between their appearance in …