A test in context: lipoprotein (a) diagnosis, prognosis, controversies, and emerging therapies

S Tsimikas - Journal of the American College of Cardiology, 2017 - jacc.org
Evidence that elevated lipoprotein (a)(Lp [a]) levels contribute to cardiovascular disease
(CVD) and calcific aortic valve stenosis (CAVS) is substantial. Development of isoform …

NHLBI working group recommendations to reduce lipoprotein (a)-mediated risk of cardiovascular disease and aortic stenosis

S Tsimikas, S Fazio, KC Ferdinand… - Journal of the American …, 2018 - jacc.org
Pathophysiological, epidemiological, and genetic studies provide strong evidence that
lipoprotein (a)[Lp (a)] is a causal mediator of cardiovascular disease (CVD) and calcific …

The dedicated “Lp (a) clinic”: a concept whose time has arrived?

S Tsimikas, ESG Stroes - Atherosclerosis, 2020 - Elsevier
The emergence of pathophysiological, epidemiologic, and genetic data strongly supports
the causality for lipoprotein (a)[Lp (a)] in cardiovascular disease (CVD) and calcific aortic …

When should we measure lipoprotein (a)?

KM Kostner, W März, GM Kostner - European heart journal, 2013 - academic.oup.com
Recently published epidemiological and genetic studies strongly suggest a causal
relationship of elevated concentrations of lipoprotein (a)[Lp (a)] with cardiovascular disease …

The renaissance of lipoprotein (a): brave new world for preventive cardiology?

KL Ellis, MB Boffa, A Sahebkar, ML Koschinsky… - Progress in Lipid …, 2017 - Elsevier
Abstract Lipoprotein (a)[Lp (a)] is a highly heritable cardiovascular risk factor. Although
discovered more than 50 years ago, Lp (a) has recently re-emerged as a major focus in the …

Lipoprotein (a): evidence for role as a causal risk factor in cardiovascular disease and emerging therapies

HS Bhatia, MJ Wilkinson - Journal of clinical medicine, 2022 - mdpi.com
Lipoprotein (a)(Lp (a)) is an established risk factor for multiple cardiovascular diseases.
Several lines of evidence including mechanistic, epidemiologic, and genetic studies support …

Lipoprotein (a) and its significance in cardiovascular disease: a review

FD Lau, RP Giugliano - JAMA cardiology, 2022 - jamanetwork.com
Importance Lipoprotein (a)(Lp [a]) is a low-density lipoprotein (LDL) cholesterol–like particle
bound to apolipoprotein (a). This novel marker of cardiovascular disease acts through …

[HTML][HTML] Global think tank on the clinical considerations and management of lipoprotein (a): The top questions and answers regarding what clinicians need to know

SS Virani, ML Koschinsky, L Maher, A Mehta… - Progress in …, 2022 - Elsevier
Evidence from Mendelian randomization studies suggest that lipoprotein (a)(Lp (a)) has a
causal role in the development of atherosclerotic cardiovascular disease risk. However …

Lipoprotein (a) and cardiovascular disease: prediction, attributable risk fraction, and estimating benefits from novel interventions

P Welsh, C Welsh, CA Celis-Morales… - European Journal of …, 2021 - academic.oup.com
Aims To investigate the population attributable fraction due to elevated lipoprotein (a)(Lp (a))
and the utility of measuring Lp (a) in cardiovascular disease (CVD) risk prediction. Methods …

Lipoprotein (a): a risk factor for atherosclerosis and an emerging therapeutic target

SA Di Fusco, M Arca, P Scicchitano, A Alonzo… - Heart, 2023 - heart.bmj.com
Lipoprotein (a)(Lp (a)) is a complex circulating lipoprotein, and increasing evidence has
demonstrated its role as a risk factor for atherosclerotic cardiovascular disease (ASCVD) …