The ALSFRS-R: a revised ALS functional rating scale that incorporates assessments of respiratory function

JM Cedarbaum, N Stambler, E Malta, C Fuller… - Journal of the …, 1999 - Elsevier
The ALS Functional Rating Scale (ALSFRS) is a validated rating instrument for monitoring
the progression of disability in patients with amyotrophic lateral sclerosis (ALS). One …

Performance of the amyotrophic lateral sclerosis functional rating scale (ALSFRS) in multicenter clinical trials

JM Cedarbaum, N Stambler - Journal of the neurological sciences, 1997 - Elsevier
The Amyotrophic Lateral Sclerosis Functional Rating Scale (ALSFRS) is a 10-item functional
inventory which was devised for use in therapeutic trials in ALS. Each item is rated on a 0–4 …

ALSFRS-R-SE: an adapted, annotated, and self-explanatory version of the revised amyotrophic lateral sclerosis functional rating scale

A Maier, M Boentert, P Reilich, S Witzel, S Petri… - … research and practice, 2022 - Springer
Abstract Background The ALS Functional Rating Scale in its revised version (ALSFRS-R) is
a disease-specific severity score that reflects motor impairment and functional deterioration …

Assessment of the factorial validity and reliability of the ALSFRS-R: a revision of its measurement model

LA Bakker, CD Schröder, MA van Es, P Westers… - Journal of …, 2017 - Springer
The amyotrophic lateral sclerosis functional rating scale-revised (ALSFRS-R) is a widely
used primary outcome measure in amyotrophic lateral sclerosis (ALS) clinical practice and …

Measuring function in advanced ALS: validation of ALSFRS‐EX extension items

P Wicks, MP Massagli, C Wolf… - European Journal of …, 2009 - Wiley Online Library
Background: With the aid of assistive technology, some patients with amyotrophic lateral
sclerosis (ALS) are able to live for several years past the lowest measurable level of function …

What does the ALSFRS-R really measure? A longitudinal and survival analysis of functional dimension subscores in amyotrophic lateral sclerosis

J Rooney, T Burke, A Vajda, M Heverin… - Journal of Neurology …, 2017 - jnnp.bmj.com
Introduction ALS functional rating scale (revised)(ALSFRS-R) is the most widely used
functional rating system in patients with amyotrophic lateral sclerosis (ALS). However …

Development and validation of a short measure of health status for individuals with amyotrophic lateral sclerosis/motor neurone disease: the ALSAQ-40

C Jenkinson, C Brennan, R Fitzpatrick, M Bromberg… - Journal of …, 1999 - Springer
In recent years there has been an increased appreciation of the importance of measuring
health status from the patient's point of view, but until now no attempt has been made to …

Evidence of multidimensionality in the ALSFRS-R Scale: a critical appraisal on its measurement properties using Rasch analysis

F Franchignoni, G Mora, A Giordano… - Journal of Neurology …, 2013 - jnnp.bmj.com
Objective To examine dimensionality, reliability and validity of the Amyotrophic Lateral
Sclerosis Functional Rating Scale-revised (ALSFRS-R) using traditional classical test theory …

Qualitative measures that assess functional disability and quality of life in ALS

SL Hartmaier, T Rhodes, SF Cook, C Schlusser… - Health and quality of life …, 2022 - Springer
Background Selection of appropriate trial endpoints and outcome measures is particularly
important in rare disease and rapidly progressing disease such as amyotrophic lateral …

Use of respiratory function tests to predict survival in amyotrophic lateral sclerosis

F Baumann, RD Henderson, SC Morrison… - Amyotrophic Lateral …, 2010 - Taylor & Francis
Respiratory function tests (RFTs) are commonly used as a measure of progression in ALS.
This study assessed the ability of various RFTs to predict survival in ALS patients. Subjects …