Cone-like morphological, molecular, and electrophysiological features of the photoreceptors of the Nrl knockout mouse
LL Daniele, C Lillo, AL Lyubarsky… - … & visual science, 2005 - iovs.arvojournals.org
purpose. To test the hypothesis that Nrl−/− photoreceptors are cones, by comparing them
with WT rods and cones using morphological, molecular, histochemical, and …
with WT rods and cones using morphological, molecular, histochemical, and …
Photoreceptors of Nrl −/− Mice Coexpress Functional S- and M-cone Opsins Having Distinct Inactivation Mechanisms
SS Nikonov, LL Daniele, X Zhu, CM Craft… - The Journal of general …, 2005 - rupress.org
The retinas of mice null for the neural retina leucine zipper transcription factor (Nrl−/−)
contain no rods but are populated instead with photoreceptors that on ultrastructural …
contain no rods but are populated instead with photoreceptors that on ultrastructural …
Recessive NRL mutations in patients with clumped pigmentary retinal degeneration and relative preservation of blue cone function
KM Nishiguchi, JS Friedman… - Proceedings of the …, 2004 - National Acad Sciences
Mice lacking the transcription factor Nrl have no rod photoreceptors and an increased
number of short-wavelength-sensitive cones. Missense mutations in NRL are associated …
number of short-wavelength-sensitive cones. Missense mutations in NRL are associated …
Expression profiling of the developing and mature Nrl −/− mouse retina: identification of retinal disease candidates and transcriptional regulatory targets …
S Yoshida, AJ Mears, JS Friedman… - Human molecular …, 2004 - academic.oup.com
The rod photoreceptor-specific neural retina leucine zipper protein Nrl is essential for rod
differentiation and plays a critical role in regulating gene expression. In the mouse retina …
differentiation and plays a critical role in regulating gene expression. In the mouse retina …
In vivo function of the orphan nuclear receptor NR2E3 in establishing photoreceptor identity during mammalian retinal development
H Cheng, TS Aleman, AV Cideciyan… - Human molecular …, 2006 - academic.oup.com
Rod and cone photoreceptors in mammalian retina are generated from common pool (s) of
neuroepithelial progenitors. NRL, CRX and NR2E3 are key transcriptional regulators that …
neuroepithelial progenitors. NRL, CRX and NR2E3 are key transcriptional regulators that …
A typology of photoreceptor gene expression patterns in the mouse
JC Corbo, CA Myers, KA Lawrence… - Proceedings of the …, 2007 - National Acad Sciences
Mutations in photoreceptor-enriched genes have been implicated in dozens of human
retinal diseases, yet no systematic analysis of rod and cone gene expression patterns has …
retinal diseases, yet no systematic analysis of rod and cone gene expression patterns has …
The rod photoreceptor-specific nuclear receptor Nr2e3 represses transcription of multiple cone-specific genes
This study addresses one genetic regulatory mechanism that establishes the distinct
identities of rod and cone photoreceptors. Previous work has shown that mutations in either …
identities of rod and cone photoreceptors. Previous work has shown that mutations in either …
A hybrid photoreceptor expressing both rod and cone genes in a mouse model of enhanced S-cone syndrome
Rod and cone photoreceptors subserve vision under dim and bright light conditions,
respectively. The differences in their function are thought to stem from their different gene …
respectively. The differences in their function are thought to stem from their different gene …
Excess cones in the retinal degeneration rd7 mouse, caused by the loss of function of orphan nuclear receptor Nr2e3, originate from early-born photoreceptor …
H Cheng, NW Khan, JE Roger… - Human molecular …, 2011 - academic.oup.com
The orphan nuclear receptor NR2E3 is a direct transcriptional target of NRL, the key basic
motif leucine zipper transcription factor that dictates rod versus cone photoreceptor cell fate …
motif leucine zipper transcription factor that dictates rod versus cone photoreceptor cell fate …
Preservation of cone photoreceptors after a rapid yet transient degeneration and remodeling in cone-only Nrl−/− mouse retina
JE Roger, K Ranganath, L Zhao… - Journal of …, 2012 - Soc Neuroscience
Cone photoreceptors are the primary initiator of visual transduction in the human retina.
Dysfunction or death of rod photoreceptors precedes cone loss in many retinal and macular …
Dysfunction or death of rod photoreceptors precedes cone loss in many retinal and macular …