As a naturally occurring cytolytic peptide, melittin (MLT) not only exhibits a potent direct
tumor cell-killing effect but also possesses various immunomodulatory functions. MLT shows …

Melittin (MEL) is a 26-amino acid polypeptide with a variety of pharmacological and
toxicological effects, which include strong surface activity on cell lipid membranes, hemolytic …

Melittin (MLT) has been studied preclinically as an anticancer agent based on its broad lytic
effects in multiple tumor types. However, unsatisfactory tissue distribution, hemolysis, rapid …

Melittin, the primary peptide component of bee venom, is a potent cytolytic anti-cancer
peptide with established anti-tumor activity. However, practical application of melittin in …

The in vivo application of cytolytic peptides for cancer therapeutics is hampered by toxicity,
nonspecificity, and degradation. We previously developed a specific strategy to synthesize a …

Melittin is a potential anticancer candidate with remarkable antitumor activity and ability to
overcome tumor drug resistance. However, the clinical applications of melittin are largely …

Melittin (MLT), as a natural active biomolecule, can penetrate the tumor cell membrane to
play a role in cancer treatment and will attract more attention in future development of …

Although peptide therapeutics have been explored for decades, the successful delivery of
potent peptides in vitro and in vivo remains challenging due to the poor stability, low cell …

The cytolytic peptide melittin is a potential anticancer candidate that may be able to
overcome tumor drug resistance due to its lytic properties. However, in vivo applications of …

Melittin, a main component of bee venom, is a cationic amphiphilic peptide with a linear α-
helix structure. It has been reported that melittin can exert pharmacological effects, such as …