[HTML][HTML] Targeting membrane-bound viral RNA synthesis reveals potent inhibition of diverse coronaviruses including the middle East respiratory syndrome virus
Coronaviruses raise serious concerns as emerging zoonotic viruses without specific antiviral
drugs available. Here we screened a collection of 16671 diverse compounds for anti-human …
drugs available. Here we screened a collection of 16671 diverse compounds for anti-human …
Conserved coronavirus proteins as targets of broad-spectrum antivirals
Coronaviruses are a class of single-stranded, positive-sense RNA viruses that have caused
three major outbreaks over the past two decades: Middle East respiratory syndrome–related …
three major outbreaks over the past two decades: Middle East respiratory syndrome–related …
[HTML][HTML] Mechanisms of coronavirus nsp1-mediated control of host and viral gene expression
K Nakagawa, S Makino - Cells, 2021 - mdpi.com
Many viruses disrupt host gene expression by degrading host mRNAs and/or manipulating
translation activities to create a cellular environment favorable for viral replication. Often …
translation activities to create a cellular environment favorable for viral replication. Often …
Middle East respiratory syndrome coronavirus nsp1 inhibits host gene expression by selectively targeting mRNAs transcribed in the nucleus while sparing mRNAs of …
KG Lokugamage, K Narayanan, K Nakagawa… - Journal of …, 2015 - Am Soc Microbiol
ABSTRACT The newly emerged Middle East respiratory syndrome coronavirus (MERS-
CoV) and severe acute respiratory syndrome CoV (SARS-CoV) represent highly pathogenic …
CoV) and severe acute respiratory syndrome CoV (SARS-CoV) represent highly pathogenic …
Recent discovery and development of inhibitors targeting coronaviruses
T Pillaiyar, S Meenakshisundaram, M Manickam - Drug discovery today, 2020 - Elsevier
Human coronaviruses (CoVs) are enveloped viruses with a positive-sense single-stranded
RNA genome. Currently, six human CoVs have been reported including human coronavirus …
RNA genome. Currently, six human CoVs have been reported including human coronavirus …
The endonucleolytic RNA cleavage function of nsp1 of Middle East respiratory syndrome coronavirus promotes the production of infectious virus particles in specific …
K Nakagawa, K Narayanan, M Wada, VL Popov… - Journal of …, 2018 - Am Soc Microbiol
Middle East respiratory syndrome coronavirus (MERS-CoV) nsp1 suppresses host gene
expression in expressed cells by inhibiting translation and inducing endonucleolytic …
expression in expressed cells by inhibiting translation and inducing endonucleolytic …
Broad-spectrum coronavirus antiviral drug discovery
AL Totura, S Bavari - Expert opinion on drug discovery, 2019 - Taylor & Francis
Introduction: The highly pathogenic coronaviruses severe acute respiratory syndrome
coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV) …
coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV) …
Expression and cleavage of middle east respiratory syndrome coronavirus nsp3-4 polyprotein induce the formation of double-membrane vesicles that mimic those …
D Oudshoorn, K Rijs, RWAL Limpens, K Groen… - MBio, 2017 - Am Soc Microbiol
ABSTRACT Betacoronaviruses, such as Middle East respiratory syndrome coronavirus
(MERS-CoV), are important pathogens causing potentially lethal infections in humans and …
(MERS-CoV), are important pathogens causing potentially lethal infections in humans and …
Middle East respiratory syndrome coronavirus NS4b protein inhibits host RNase L activation
Middle East respiratory syndrome coronavirus (MERS-CoV) is the first highly pathogenic
human coronavirus to emerge since severe acute respiratory syndrome coronavirus (SARS …
human coronavirus to emerge since severe acute respiratory syndrome coronavirus (SARS …
Coronaviruses resistant to a 3C-like protease inhibitor are attenuated for replication and pathogenesis, revealing a low genetic barrier but high fitness cost of …
Viral protease inhibitors are remarkably effective at blocking the replication of viruses such
as human immunodeficiency virus and hepatitis C virus, but they inevitably lead to the …
as human immunodeficiency virus and hepatitis C virus, but they inevitably lead to the …