Standardised management of tuberculosis may soon be replaced by individualised,
precision medicine-guided therapies informed with knowledge provided by the field of …

Due to the complexity of the immune response to a Mycobacterium tuberculosis infection,
identifying new, effective therapies and vaccines to combat it has been a problematic issue …

Tuberculosis is a bacterial infectious disease that is mainly transmitted from human to
human via infectious aerosols. Currently, tuberculosis is the leading cause of death by an …

The advent of high-throughput platforms for the interrogation of biological systems at the
cellular and molecular levels has allowed living cells to be observed and understood at a …

Supplementary Data Supplementary materials are available at Clinical Infectious Diseases
online. Consisting of data provided by the authors to benefit the reader, the posted materials …

Introduction Despite the introduction of new tests and guidelines for diagnosis of
tuberculosis (TB), worldwide case detection rate of TB is still suboptimal. This could be in …

Abstract Each year, 1.3 million people die from tuberculosis, an infectious disease caused
by Mycobacterium tuberculosis. Systems biology-based strategies might significantly …

Transcriptional profiling has revealed that Mycobacterium tuberculosis adapts both its
metabolic and respiratory states during infection, utilising lipids as a carbon source and …

Systems biology seeks to study biological systems as a whole, by adopting an integrated
approach to study and understand the function of biological systems, particularly, the …

Background Systematic reviews are increasingly informing policies in tuberculosis (TB) care
and control. They may also be a source of questions for future research. As part of the …