Induced Pluripotent Stem Cells in Disease Biology and the Evidence for Their In Vitro Utility

A Adegunsoye, NM Gonzales… - Annual Review of …, 2023 - annualreviews.org
Many human phenotypes are impossible to recapitulate in model organisms or immortalized
human cell lines. Induced pluripotent stem cells (iPSCs) offer a way to study disease …

Induced pluripotent stem cells in disease modeling and gene identification

S Kumar, J Blangero, JE Curran - Disease gene identification: methods …, 2018 - Springer
Experimental modeling of human inherited disorders provides insight into the cellular and
molecular mechanisms involved, and the underlying genetic component influencing, the …

Induced pluripotent stem cells in disease modelling and drug discovery

RG Rowe, GQ Daley - Nature Reviews Genetics, 2019 - nature.com
The derivation of induced pluripotent stem cells (iPSCs) over a decade ago sparked
widespread enthusiasm for the development of new models of human disease, enhanced …

A practical guide to induced pluripotent stem cell research using patient samples

KE Santostefano, T Hamazaki, NM Biel, S Jin… - Laboratory …, 2015 - nature.com
Approximately 3 years ago, we assessed how patient induced pluripotent stem cell (iPSC)
research could potentially impact human pathobiology studies in the future. Since then, the …

Induced pluripotent stem cells—opportunities for disease modelling and drug discovery

M Grskovic, A Javaherian, B Strulovici… - Nature reviews Drug …, 2011 - nature.com
The ability to generate induced pluripotent stem cells (iPSCs) from patients, and an
increasingly refined capacity to differentiate these iPSCs into disease-relevant cell types …

High-throughput and cost-effective characterization of induced pluripotent stem cells

M D'Antonio, G Woodruff, JL Nathanson… - Stem cell reports, 2017 - cell.com
Reprogramming somatic cells to induced pluripotent stem cells (iPSCs) offers the possibility
of studying the molecular mechanisms underlying human diseases in cell types difficult to …

Diseases in a dish: modeling human genetic disorders using induced pluripotent cells

G Tiscornia, EL Vivas, JCI Belmonte - Nature medicine, 2011 - nature.com
The derivation of induced pluripotent cells (iPSCs) from individuals suffering from genetic
syndromes offers new opportunities for basic research into these diseases and the …

Induced pluripotent stem cells for modelling human diseases

JJ Unternaehrer, GQ Daley - … Transactions of the Royal …, 2011 - royalsocietypublishing.org
Research into the pathophysiological mechanisms of human disease and the development
of targeted therapies have been hindered by a lack of predictive disease models that can be …

Systems-wide approaches in induced pluripotent stem cell models

E Lau, DT Paik, JC Wu - Annual Review of Pathology …, 2019 - annualreviews.org
Human induced pluripotent stem cells (iPSCs) provide a renewable supply of patient-
specific and tissue-specific cells for cellular and molecular studies of disease mechanisms …

Induced pluripotent stem cells and their use in human models of disease and development

P Karagiannis, K Takahashi, M Saito… - Physiological …, 2019 - journals.physiology.org
The discovery of somatic cell nuclear transfer proved that somatic cells can carry the same
genetic code as the zygote, and that activating parts of this code are sufficient to reprogram …