Multiple sclerosis (MS) lesions that do not resolve in the months after they form harbour
ongoing demyelination and axon degeneration, and are identifiable in vivo by their …

Multiple sclerosis (MS) is a neuroinflammatory disease with a relapsing–remitting disease
course at early stages, distinct lesion characteristics in cortical grey versus subcortical white …

Pro-inflammatory T cells in the central nervous system (CNS) are causally associated with
multiple demyelinating and neurodegenerative diseases,,,,–, but the pathways that control …

Despite the development of highly effective treatments for relapsing–remitting multiple
sclerosis (MS), limited progress has been made in addressing primary progressive or …

Multiple Sclerosis (MS) is a neurodegenerative disease characterized by multiple focal
lesions, ongoing demyelination and, for most people, a lack of remyelination. MS lesions are …

Multiple sclerosis is an immune-mediated chronic inflammatory disease of the CNS that
leads to demyelinated lesions in the grey and white matter. Inflammatory, active …

The predominant type of immune cell in the brain is the microglia, a type of tissue-resident
macrophage. In a variety of neurodegenerative settings, microglia alter their transcriptional …

Therapeutically controlling chronic progression in multiple sclerosis (MS) remains a major
challenge. MS progression is defined as a steady loss of parenchymal and functional …

Microglia originate from myeloid progenitors in the embryonic yolk sac and play an integral
role in central nervous system (CNS) development, immune surveillance and repair. The …

Multiple sclerosis: trapped in deadly glue | Nature Medicine Skip to main content Thank you for
visiting nature.com. You are using a browser version with limited support for CSS. To obtain …