In the antibacterial arsenal, β-lactams have held a prominent position, but increasing
resistance due to unauthorized use and genetic factors requires new strategies. Combining …

Abstract β-lactam resistance in bacteria is primarily mediated through the production of β-
lactamases. Among the several strategies explored to mitigate the issue of β-lactam …

Drug resistance is an unsolved and major concern in the bacterial infection. Continuous
development of drug-resistance to the antibiotics exponentially rises the danger of bacterial …

Introduction Antibacterial drugs have been widely used for the past century to treat diseases,
but their efficacy has been limited by multi-resistant pathogens, particularly those that utilize …

The β-lactamase of Pseudomonas aeruginosa is known to degrade β-lactam antibiotics
such as penicillins, cephalosporins, monobactams, and carbapenems. With the discovery of …

Background: Staphylococcus aureus (S. aureus) is a Gram-positive bacterium causing a
wide range of human infections, leading to life-threatening invasive disorders …

Antibiotic resistance is threatening the medical industry in treating microbial infections. Many
organisms are acquiring antibiotic resistance because of the continuous use of the same …

Extended-spectrum beta-lactamase (ESBL) producing Enterobacteriaceae infection is a
serious global threat. ESBLs target 3rd generation cephalosporin antibiotics, the most …

Abstract β-lactamase are the main resistance factor for β-lactam antibiotics in Gram-negative
bacteria. Since β-lactam antibiotics are being utilised as an antimicrobial agents extensively …

Amid the rise of multi-drug resistance among bacterial pathogens, the drying of the
development pipeline of new antibiotics is worrisome. In search of new effective alternatives …