Nitric oxide (NO) molecular messenger can reverse the multidrug resistance (MDR) effect of
cancer cells through reducing P-glycoprotein (P-gp) expression, beneficial for creating a …

Gas therapy has emerged as a forceful strategy for augmenting the effects of
chemotherapeutic drugs against cancer cells. However, it remains extremely challenging to …

Multidrug resistance (MDR) is responsible for the relatively low effectiveness of
chemotherapeutics. Herein, a nitric oxide (NO) gas-enhanced chemosensitization strategy is …

Multiple biological barriers in solid tumors severely restrict the penetration of
nanomedicines, which is a main cause for therapeutic failure in traditional tumor treatment …

Multidrug resistance (MDR) of cancer is a challenge to effective chemotherapeutic
interventions. The stimulus-responsive drug delivery system (DDS) based on …

Poor permeation of therapeutic agents and multidrug resistance (MDR) in solid tumors are
the two major challenges that lead to the failure of the current chemotherapy methods …

Clinical chemotherapy for cancer is limited by the physiological barrier of tumors, resulting in
low drug delivery to tumors, poor efficacy of drugs and inability to block tumor metastasis …

Hypoxia, a common feature of most solid tumors, causes severe tumor resistance to
chemotherapy and immunotherapy. Herein, a tumor-acidity and bioorthogonal chemistry …

Macrophages are known to penetrate tumor central hypoxic areas and hold great potential
in cancer drug delivery. However, it remains a big challenge for current macrophage-based …

Background Triple negative breast cancer (TNBC) is one of the most aggressive tumors with
high metastasis and mortality, which constitutes 15~ 20% of all breast cancers …