Effects of chemotherapy and immunotherapy on microbial diversity in TME and engineered bacterial-mediated tumor therapy

H Zheng, X Chen, Q Li, Y Liu, J Cai - Frontiers in Immunology, 2023 - frontiersin.org
Tumor microbiota is a group of microorganisms located in tumor tissues with rich diversity
that can promote tumorigenesis and development, and different types of tumors have …

[HTML][HTML] The role of extratumoral and intratumoral microorganisms in cancer immunotherapy

Y Du, L Liu, W Ma, W Yan, W Mao, Y Du, K Cui… - The Innovation …, 2023 - the-innovation.org
Microbiome is ubiquitous in human and distributed in not only normal organs such as gut,
but also in tumor tissues of the host. Numerous studies have proven that the extratumoral …

The role of the tumor microbiome in tumor development and its treatment

Y Chen, FH Wu, PQ Wu, HY Xing, T Ma - Frontiers in Immunology, 2022 - frontiersin.org
Commensal bacteria and other microorganisms that reside in the human body are closely
associated with the development and treatment of cancers. Recently, tumor microbiome …

[HTML][HTML] Current status of intratumour microbiome in cancer and engineered exogenous microbiota as a promising therapeutic strategy

J Chen, T Li, J Liang, Q Huang, JD Huang, Y Ke… - Biomedicine & …, 2022 - Elsevier
Research on the relationship between microbiome and cancer has made significant
progress in the past few decades. It is now known that the gut microbiome has multiple …

New insights into the role of tumor microbial microenvironment in tumor immunotherapy

P Dong, X Chen, J Tang, W Wang - Frontiers in Cellular and Infection …, 2024 - frontiersin.org
In a study by Liu et al., machine learning algorithms were deployed to discern key
determinants of survival in gastric cancer patients undergoing radical surgery and …

The intratumoural microbiota in cancer: new insights from inside

Y An, W Zhang, T Liu, B Wang, H Cao - Biochimica et Biophysica Acta (BBA …, 2021 - Elsevier
The human body harbors a vast array of microbiota that modulates host pathophysiological
processes and modifies the risk of diseases including cancer. With the advent of …

Exploiting bacteria for cancer immunotherapy

SY Kwon, H Thi-Thu Ngo, J Son, Y Hong… - Nature Reviews Clinical …, 2024 - nature.com
Immunotherapy has revolutionized the treatment of cancer but continues to be constrained
by limited response rates, acquired resistance, toxicities and high costs, which necessitates …

Tumor microbiome–an integral part of the tumor microenvironment

S Ciernikova, A Sevcikova, V Stevurkova… - Frontiers in …, 2022 - frontiersin.org
The tumor microenvironment (TME) plays a significant role in tumor progression and cancer
cell survival. Besides malignant cells and non-malignant components, including immune …

[HTML][HTML] Tweak to treat: reprograming bacteria for cancer treatment

BFL Sieow, KS Wun, WP Yong, IY Hwang, MW Chang - Trends in cancer, 2021 - cell.com
Recent advancements in cancer biology, microbiology, and bioengineering have spurred
the development of engineered live biotherapeutics for targeted cancer therapy. In …

[HTML][HTML] Oncolytic bacteria and their potential role in bacterium-mediated tumour therapy: a conceptual analysis

Y Wang, W Guo, XL Wu, Y Zhang, C Mannion… - Journal of …, 2019 - ncbi.nlm.nih.gov
As the human microbiota has been confirmed to be of great significance in maintaining
health, the dominant bacteria in them have been applied as probiotics to treat various …