Microtubules are protein biopolymers formed through polymerization of heterodimers of α-
and β-tubulins. Disruption of microtubules can induce cell cycle arrest in G 2-M phase and …

Novel indazole and benzimidazole analogues were designed and synthesized as tubulin
inhibitors with potent antiproliferative activities. Among them, compound 12b exhibited the …

The α-and β-tubulins are the major polypeptide components of microtubules (MTs), which
are attractive targets for anticancer drug development. Indole derivatives display a variety of …

Introduction: Microtubules play an important role in several cellular processes, particularly in
the formation of the mitotic spindle during the process of mitosis. These highly dynamic …

Introduction: About 20 patents have been published from 2013 to 2018 for developing
advanced cancer therapeutics by targeting tubulin polymerization. Currently, there are …

Cancer accounts for numerous deaths each year, and it is one of the most common causes
of death worldwide, despite many breakthroughs in the discovery of novel anticancer …

Abstract By removing 5-methyl and 6-acetyl groups in our previously reported compound 3,
we designed a series of novel 2, 7-diaryl-[1, 2, 4] triazolo [1, 5-a] pyrimidine derivatives as …

We report the design, synthesis, and biological evaluation of heterocyclic-fused pyrimidines
as tubulin polymerization inhibitors targeting the colchicine binding site with significantly …

Abstract A series of Pyrazolo [1, 5-a] Pyrimidine analogs were designed and synthesized as
novel tubulin inhibitors. Among them, compounds 1a and 1b showed the highest …

Tubulin has picked up great focus as a major target in drug discovery and consequently,
tubulin inhibitors have pulling in a considerable attention as anticancer agents. Numerable …