Purpose The aim was to assess the effect of a relevant regimen of zoledronic acid (ZA)
treatment for the study of bisphosphonate-related osteonecrosis of the jaw on alveolar bone …

Long-term use of intravenous bisphosphonates, such as zoledronic acid (zoledronate), has
been linked to bisphosphonate-related osteonecrosis of the jaw (BRONJ). Invasive dental …

Objectives Pathogenesis of bisphosphonate-related osteonecrosis of the jaws (BRONJ) is
not fully explained. An antiangiogenic effect of bisphosphonates (BPs) or an altered bone …

Objectives To establish osteonecrosis of the jaws in rats treated with different doses of
zoledronic acid (ZA). Methods Male Wistar rats (n= 6–7) received three consecutive weekly …

Introduction Bisphosphonate-related osteonecrosis of the jaws (BRONJ) is a pathologic
condition of increasing frequency, with a poorly understood pathophysiology and which can …

J Oral Pathol Med (2010) 39: 390–396 The aim of this study was to evaluate a novel animal
model of bisphosphonates‐associated osteonecrosis, which realistically recapitulates the …

Oral Diseases (2011) 17, 291–297 Objective: Osteonecrosis of the jaw is a serious
complication of bisphosphonate treatment for which the pathophysiology is unknown. The …

Background Bisphosphonate (BP)-associated osteonecrosis of the jaw (ONJ) has been
reported in patients receiving intravenous BP, particularly zoledronic acid (ZA). The purpose …

The pathophysiology, histopathology, and immunopathology of bisphosphonate-related
osteonecrosis of the jaw (BRONJ) Stage 0 remain unclear. The aim of this study was to …

Zoledronic acid (ZA), which is one of the most potent and efficacious bisphosphonates, has
been commonly used in clinical practice for the treatment of various bone disorders. The …