Sesamol attenuates scopolamine-induced cholinergic disorders, neuroinflammation, and cognitive deficits in mice

D Yun, Y Wang, Y Zhang, M Jia, T Xie… - Journal of Agricultural …, 2022 - ACS Publications
Alzheimer's disease (AD) is a neurodegenerative disease, characterized by memory loss
and cognitive deficits accompanied by neuronal damage and cholinergic disorders …

Protective effects of sesamol on systemic inflammation and cognitive impairment in aging mice

B Ren, T Yuan, X Zhang, L Wang, J Pan… - Journal of agricultural …, 2020 - ACS Publications
Sesamol, a lignan in sesame, possesses several bioactivities, such as antioxidation, anti-
inflammation, and neuroprotective capability. In this study, the effects of sesamol on aging …

Sesamol attenuates amyloid peptide accumulation and cognitive deficits in APP/PS1 mice: The mediating role of the gut–brain axis

Q Liu, T Xie, Y Xi, L Li, F Mo, X Liu, Z Liu… - Journal of Agricultural …, 2021 - ACS Publications
Alzheimer's disease (AD), a neurodegenerative disease, is the leading cause of dementia.
Sesamol is a lignan extracted from sesame oil and has been found to exert neuroprotective …

Apoe-dependent protective effects of sesamol on high-fat diet-induced behavioral disorders: Regulation of the microbiome-gut–brain axis

T Yuan, C Chu, R Shi, T Cui, X Zhang… - Journal of agricultural …, 2019 - ACS Publications
Sesamol, an antioxidant lignan from sesame oil, possesses neuroprotective bioactivities.
The present work was aimed to elucidate the systemic protective effects of sesamol on …

Protective effects of sesamol on systemic oxidative stress-induced cognitive impairments via regulation of Nrf2/Keap1 pathway

B Ren, T Yuan, Z Diao, C Zhang, Z Liu, X Liu - Food & function, 2018 - pubs.rsc.org
Oxidative stress is considered as a pivotal culprit in neurodegenerative diseases and brain
aging. The aim of present study was to investigate antioxidative and neuroprotective effects …

Sesamin suppresses LPS-induced microglial activation via regulation of TLR4 expression

S Udomruk, C Kaewmool, P Pothacharoen… - Journal of Functional …, 2018 - Elsevier
Sesamin, one of the most abundant lignans in sesame seeds and oils, is well known for
neuroprotective activity. However, its effects on toll-like-receptor 4 (TLR4), the key innate …

Sesamol supplementation prevents systemic inflammation‐induced memory impairment and amyloidogenesis via inhibition of nuclear factor kappaB

Z Liu, Y Chen, Q Qiao, Y Sun, Q Liu… - Molecular Nutrition & …, 2017 - Wiley Online Library
Scope The aim of the present study was to investigate the inhibitory effects of sesamol, a
phenolic lignan from sesame, on the systemic inflammation‐induced neuroinflammation and …

Sesamin imparts neuroprotection against intrastriatal 6-hydroxydopamine toxicity by inhibition of astroglial activation, apoptosis, and oxidative stress

T Baluchnejadmojarad, M Mansouri, J Ghalami… - Biomedicine & …, 2017 - Elsevier
Parkinson's disease (PD) is one of the most prevalent neurodegenerative disorders in
elders. Sesamin is a lignan compound and the active constituent of sesame oil with …

[HTML][HTML] Lignan-Rich Sesame (Sesamum indicum L.) Cultivar Exhibits In Vitro Anti-Cholinesterase Activity, Anti-Neurotoxicity in Amyloid-β Induced SH-SY5Y Cells …

MY Kim, S Kim, J Lee, JI Kim, E Oh, SW Kim, E Lee… - Antioxidants, 2023 - mdpi.com
Alzheimer's disease, a major cause of dementia, is characterized by impaired cholinergic
function, increased oxidative stress, and amyloid cascade induction. Sesame lignans have …

Hesperetin attenuates cognitive dysfunction via SIRT6/NLRP3 pathway in scopolamine-induced mice

S Jing, X Wang, Z Zhang, D Cao, K Huang… - Metabolic Brain …, 2023 - Springer
Neuroinflammation is a critical feature in the pathogenesis of neurodegenerative disorders
such as Alzheimer's disease (AD). Hesperetin can exert anti-inflammatory, antioxidant and …