Human colorectal carcinoma (CRC) is one of the leading cancers. Every year, the WHO
estimates a total of 945,000 new CRC cases, with 492,000 deaths worldwide. Most CRCs …

It is believed that chronic inflammation as seen in patients with ulcerative colitis significantly
increases the colorectal cancer (CRC) risk and functions as the main driving force for the …

Colorectal cancer (CRC) remains one of the major public health problems throughout the
world. Originally depicted as a multi-step dynamical disease, CRC develops slowly over …

Introduction Colorectal cancer (CRC) still represents the third most commonly diagnosed
type of cancer in men and women worldwide. CRC is acknowledged as a heterogeneous …

Colorectal cancer is one of the leading causes of cancer-related deaths worldwide. The
tumor microenvironment is of great biological importance in cancer development and …

Colorectal cancer (CRC) represents a molecularly heterogeneous disease and one of the
most frequent causes of cancer-related death worldwide. The traditional classification of …

Cytokines have been suggested to be key factors in modulating immune response against
tumorigenesis in the microenvironment. Therefore, characterization of cytokine expression …

It is now widely accepted that most human cancers, including colorectal cancers (CRCs),
develop from premalignant lesions through a long-term multistep process. Host immunity is …

Inflammatory cells are involved in tumour initiation and progression. In parallel, the adaptive
immune response plays a key role in fighting tumour growth and dissemination. The double …

Colorectal cancer (CRC) is a major cause of mortality and morbidity worldwide. Inflammatory
activity within the stroma of invasive colorectal tumours is known to be a key predictor of …