Background Alzheimer's disease (AD) represents profound degenerative conditions of the
brain that cause significant deterioration in memory and cognitive function. Despite …

Background There is an urgent need to understand the pathways and processes underlying
Alzheimer's disease (AD) for early diagnosis and development of effective treatments. This …

Background Lipid metabolism changes occur in early Alzheimer's disease (AD) patients. Yet
little is known about metabolic gene changes in early AD cortex. Methods The lipid …

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the
accumulation of amyloid-β (Aβ) plaques followed by intracellular neurofibrillary tangles …

Background: Alzheimer Disease (AD) is the most prevalent dementia. However, the
physiopathological mechanisms involved in its development are unclear. In this sense, a …

Lipidomics research could provide insights of pathobiological mechanisms in Alzheimer's
disease. This study explores a battery of plasma lipids that can differentiate Alzheimer's …

Alzheimer's disease (AD) is a highly prevalent neurodegenerative disorder. Despite
increasing evidence of the importance of metabolic dysregulation in AD, the underlying …

Introduction At least one-third of the identified risk alleles from Genome-Wide Association
Studies (GWAS) of Alzheimer's disease (AD) are involved in lipid metabolism, lipid transport …

In recent years, several pathway analyses of genome-wide association studies reported the
involvement of metabolic and immune pathways in Alzheimer's disease (AD). Until now, the …

Background: Currently, there is no objective, clinically available tool for the accurate
diagnosis of Alzheimer's disease (AD). There is a pressing need for a novel, minimally …