Identification of key lipid metabolism-related genes in Alzheimer's disease
Y Zeng, S Cao, N Li, J Tang, G Lin - Lipids in Health and Disease, 2023 - Springer
Background Alzheimer's disease (AD) represents profound degenerative conditions of the
brain that cause significant deterioration in memory and cognitive function. Despite …
brain that cause significant deterioration in memory and cognitive function. Despite …
Integrated lipidomics and proteomics network analysis highlights lipid and immunity pathways associated with Alzheimer's disease
Background There is an urgent need to understand the pathways and processes underlying
Alzheimer's disease (AD) for early diagnosis and development of effective treatments. This …
Alzheimer's disease (AD) for early diagnosis and development of effective treatments. This …
Cortical lipid metabolic pathway alteration of early Alzheimer's disease and candidate drugs screen
L Wang, F Qu, X Yu, S Yang, B Zhao, Y Chen… - European Journal of …, 2024 - Springer
Background Lipid metabolism changes occur in early Alzheimer's disease (AD) patients. Yet
little is known about metabolic gene changes in early AD cortex. Methods The lipid …
little is known about metabolic gene changes in early AD cortex. Methods The lipid …
Lipid metabolism transcriptomics of murine microglia in Alzheimer's disease and neuroinflammation
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the
accumulation of amyloid-β (Aβ) plaques followed by intracellular neurofibrillary tangles …
accumulation of amyloid-β (Aβ) plaques followed by intracellular neurofibrillary tangles …
Epigenomics and lipidomics integration in Alzheimer disease: pathways involved in early stages
C Peña-Bautista, L Álvarez-Sánchez… - Biomedicines, 2021 - mdpi.com
Background: Alzheimer Disease (AD) is the most prevalent dementia. However, the
physiopathological mechanisms involved in its development are unclear. In this sense, a …
physiopathological mechanisms involved in its development are unclear. In this sense, a …
Plasma lipidome is dysregulated in Alzheimer's disease and is associated with disease risk genes
Lipidomics research could provide insights of pathobiological mechanisms in Alzheimer's
disease. This study explores a battery of plasma lipids that can differentiate Alzheimer's …
disease. This study explores a battery of plasma lipids that can differentiate Alzheimer's …
Pathway‐based integration of multi‐omics data reveals lipidomics alterations validated in an Alzheimer's disease mouse model and risk loci carriers
ME Garcia‐Segura, BR Durainayagam… - Journal of …, 2023 - Wiley Online Library
Alzheimer's disease (AD) is a highly prevalent neurodegenerative disorder. Despite
increasing evidence of the importance of metabolic dysregulation in AD, the underlying …
increasing evidence of the importance of metabolic dysregulation in AD, the underlying …
Brain and serum lipidomic profiles implicate Lands cycle acyl chain remodeling association with APOEε4 and mild cognitive impairment
J Mares, AP Costa, WJ Dartora… - Frontiers in Aging …, 2024 - frontiersin.org
Introduction At least one-third of the identified risk alleles from Genome-Wide Association
Studies (GWAS) of Alzheimer's disease (AD) are involved in lipid metabolism, lipid transport …
Studies (GWAS) of Alzheimer's disease (AD) are involved in lipid metabolism, lipid transport …
[HTML][HTML] Gene expression analysis reveals the dysregulation of immune and metabolic pathways in Alzheimer's disease
J Chen, C Xie, Y Zhao, Z Li, P Xu, L Yao - Oncotarget, 2016 - ncbi.nlm.nih.gov
In recent years, several pathway analyses of genome-wide association studies reported the
involvement of metabolic and immune pathways in Alzheimer's disease (AD). Until now, the …
involvement of metabolic and immune pathways in Alzheimer's disease (AD). Until now, the …
A community-based study identifying metabolic biomarkers of mild cognitive impairment and Alzheimer's disease using artificial intelligence and machine learning
Background: Currently, there is no objective, clinically available tool for the accurate
diagnosis of Alzheimer's disease (AD). There is a pressing need for a novel, minimally …
diagnosis of Alzheimer's disease (AD). There is a pressing need for a novel, minimally …