Acute myocardial infarction (AMI) represents the leading cause of cardiovascular death
worldwide, and it is thus pivotal to develop effective approaches for the timely detection of …

Direct, rapid, sensitive, and selective detection of nucleic acids in complex biological fluids is
crucial for medical early diagnosis. We herein combine the trans-cleavage ability of …

MicroRNA (miRNA) is a promising biomarker for the diagnosis, monitoring, and prognostic
evaluation of diseases, especially cancer. The existing miRNA detection methods usually …

Mild traumatic brain injury (mTBI) may cause increasing risk of long-term sequelae during
brain development among children and adolescents. Recent investigations have declared …

MicroRNA (miRNA) play a vital role in the pathological development of many diseases. It is
considered to be the diagnosis and potential biomarkers of prognosis. Herein, we proposed …

CRISPR-driven biosensing is developing rapidly, but current studies mostly adopt dye-
labeled ssDNA as the signal reporter, which is costly and unstable. Herein, we developed a …

Herein, a chemiluminescence (CL) biosensor based on CRISPR-Cas12a and cation
exchange reaction was constructed to detect the biomarker microRNA-21 (miRNA-21). The …

MicroRNAs (miRNAs) play a very important role in biological processes and are used as
biomarkers for the detection of a variety of diseases, including neurodegenerative diseases …

MicroRNAs (miRNAs) are related to many biological processes and regarded as biomarkers
of disease. Rapid, sensitive, and specific methods for miRNA assay are very important for …

CRISPR/Cas12a shows excellent potential in disease diagnostics. However, insensitive
signal conversion strategies hindered its application in detecting protein biomarkers. Here …