L AMA2-related muscular dystrophy (LAMA2 MD or MDC1A) is the most frequent form of
early-onset, fatal congenital muscular dystrophies. It is caused by mutations in LAMA2, the …

Mutations in laminin α2-subunit (Lmα2, encoded by LAMA2) are linked to approximately
30% of congenital muscular dystrophy cases. Mice with a homozygous mutation in Lama2 …

Laminins are large heterotrimers composed of the α, β and γ subunits with distinct tissue-
specific and developmentally regulated expression patterns. The laminin-α2 subunit …

LAMA2 deficiency, resulting from a defective or absent laminin α2 subunit, is a common
cause of congenital muscular dystrophy. It is characterized by muscle weakness from …

Muscular dystrophies, including laminin α2 chain-deficient muscular dystrophy (LAMA2-
CMD), are associated with immense personal, social and economic burdens. Thus, effective …

Laminin-α2-related congenital muscular dystrophy (LAMA2-CMD) is a devastating
neuromuscular disease caused by mutations in the LAMA2 gene. These mutations result in …

An understanding of basement membrane (BM) assembly at a molecular level provides a
foundation with which to develop repair strategies for diseases with defects of BM structure …

The research on laminin α2 chain-deficient congenital muscular dystrophy (LAMA2-CMD)
advanced rapidly in the last few decades, largely due to availability of good mouse models …

Mutations in LAMA2 cause severe congenital muscular dystrophy accompanied by nervous
system defects [1]. Mice homozygous for the dy 2J allele of LAMA2 express a laminin α2 …

Mutations in the gene encoding the basal lamina (BL) component laminin α2 (LAMA2)
cause merosin-deficient congenital muscular dystrophy 1A (MDC1A), a complex disorder …