Ischemic heart disease remains one of the most prominent causes of mortalities worldwide
with heart transplantation being the gold-standard treatment option. However, due to the …

Maturation is the last phase of heart development that prepares the organ for strong,
efficient, and persistent pumping throughout the mammal's lifespan. This process is …

In the past few decades, cardiac regeneration has been the central target for restoring the
injured heart. In mammals, cardiomyocytes are terminally differentiated and rarely divide …

During cardiac development and morphogenesis, cardiac progenitor cells differentiate into
cardiomyocytes that expand in number and size to generate the fully formed heart. Much is …

Engineering functional human cardiac tissue that mimics the native adult morphological and
functional phenotype has been a long held objective. In the last 5 years, the field of cardiac …

The discovery of human pluripotent stem cells (hPSCs), including both human embryonic
stem cells and human-induced pluripotent stem cells, has opened up novel paths for a wide …

Heart attack remains the leading cause of death in both men and women worldwide. Stem
cell-based therapies, including the use of engineered cardiac tissues, have the potential to …

Through the use of stem cell-derived cardiac myocytes, tissue-engineered human
myocardial constructs are poised for modeling normal and diseased physiology of the heart …

Our knowledge of pluripotent stem cell (PSC) biology has advanced to the point where we
now can generate most cells of the human body in the laboratory. PSC-derived …

During development, cardiogenesis is orchestrated by a family of heart progenitors that build
distinct regions of the heart. Each region contains diverse cell types that assemble to form …