Fetal liver CD34+ contain human immune and endothelial progenitors and mediate solid tumor rejection in NOG mice
T Celhar, X Li, Y Zhao, HC Tay, A Lee, HH Liew… - Stem Cell Research & …, 2024 - Springer
Background Transplantation of CD34+ hematopoietic stem and progenitor cells (HSPC) into
immunodeficient mice is an established method to generate humanized mice harbouring a …
immunodeficient mice is an established method to generate humanized mice harbouring a …
Engraftment potential into NOD/SCID mice of CD34+ cells derived from human fetal liver as compared to fetal bone marrow
J Wilpshaar, WA Noort, HH Kanhai, R Willemze… - …, 2001 - haematologica.org
BACKGROUND AND OBJECTIVES: We hypothesized that qualitative or quantitative
differences in hematopoietic stem cells from fetal liver (FL) and fetal bone marrow (FBM) …
differences in hematopoietic stem cells from fetal liver (FL) and fetal bone marrow (FBM) …
Human CD34loCD133lo fetal liver cells support the expansion of human CD34hiCD133hi hematopoietic stem cells
We have recently discovered a unique CD34 lo CD133 lo cell population in the human fetal
liver (FL) that gives rise to cells in the hepatic lineage. In this study, we further characterized …
liver (FL) that gives rise to cells in the hepatic lineage. In this study, we further characterized …
[HTML][HTML] Human CD34+ cell preparations contain over 100-fold greater NOD/SCID mouse engrafting capacity than do CD34− cell preparations
Z Gao, MJ Fackler, W Leung, R Lumkul… - Experimental …, 2001 - Elsevier
OBJECTIVE: The CD34 cell surface marker is used widely for stem/progenitor cell isolation.
Since several recent studies reported that CD34− cells also have in vivo engrafting capacity …
Since several recent studies reported that CD34− cells also have in vivo engrafting capacity …
Comparison of human fetal liver, umbilical cord blood, and adult blood hematopoietic stem cell engraftment in NOD-scid/γc−/−, Balb/c-Rag1−/− γc−/−, and CB-17-scid …
CM Lepus, TF Gibson, SA Gerber, I Kawikova… - Human immunology, 2009 - Elsevier
Immunodeficient mice bearing components of a human immune system present a novel
approach for studying human immune responses. We investigated the number, phenotype …
approach for studying human immune responses. We investigated the number, phenotype …
Intrahepatic transplantation of CD34+ cord blood stem cells into newborn and adult NOD/SCID mice induce differential organ engraftment
A Wulf-Goldenberg, M Keil, I Fichtner, K Eckert - Tissue and Cell, 2012 - Elsevier
In vivo studies concerning the function of human hematopoietic stem cells (HSC) are limited
by relatively low levels of engraftment and the failure of the engrafted HSC preparations to …
by relatively low levels of engraftment and the failure of the engrafted HSC preparations to …
Robust engraftment of fetal nonhuman primate CD34-positive cells in immune-deficient mice
CJ Little, WJ Haynes, L Huang… - Journal of leukocyte …, 2022 - academic.oup.com
Nonhuman primates (NHPs) represent one of the most important models for preclinical
studies of novel biomedical interventions. In contrast with small animal models, however …
studies of novel biomedical interventions. In contrast with small animal models, however …
Engraftment and Development of Human CD34+-Enriched Cells From Umbilical Cord Blood in NOD/LtSz-scid/scid Mice
CJ Hogan, EJ Shpall, O McNulty… - Blood, The Journal …, 1997 - ashpublications.org
Understanding the repopulating characteristics of human hematopoietic stem/progenitor cell
fractions is crucial for predicting their performance after transplant into high-risk patients …
fractions is crucial for predicting their performance after transplant into high-risk patients …
Serial transfer of human hematopoietic and hepatic stem/progenitor cells
A range of assays have been developed to determine the stemness or stem cell activity of
human stem cells. The key assays of stem cells are functional: they must show self-renewal …
human stem cells. The key assays of stem cells are functional: they must show self-renewal …
[HTML][HTML] CD117hi expression identifies a human fetal hematopoietic stem cell population with high proliferation and self-renewal potential
L Maillard, S Sanfilippo, C Domenech, N Kasmi… - …, 2020 - ncbi.nlm.nih.gov
Long term culture–initiating cell (LTC-IC) assays were performed to check whether the
CD117hi population is enriched in hematopoietic stem and progenitor cells (HSPC). LTC-IC …
CD117hi population is enriched in hematopoietic stem and progenitor cells (HSPC). LTC-IC …