The pineal gland is a unique organ that synthesizes melatonin as the signaling molecule of
natural photoperiodic environment and as a potent neuronal protective antioxidant. An intact …

Alzheimer's disease (AD) is a globally common neurodegenerative disease, which is
accompanied by alterations to various lifestyle patterns, such as sleep disturbance. The …

Melatonin research has been experiencing hyper growth in the last two decades; this relates
to its numerous physiological functions including anti-inflammation, oncostasis, circadian …

Neurodegenerative diseases are the second most common cause of death and
characterized by progressive impairments in movement or mental functioning in the central …

Bone‑related diseases comprise a large group of common diseases, including fractures,
osteoporosis and osteoarthritis (OA), which affect a large number of individuals, particularly …

Melatonin has been postulated to have diverse properties, acting as an antioxidant, a
neuroprotector, or a stabilizer within the circadian timing system, and is thus thought to be …

Introduction: The pineal gland, an endocrine organ of the posterior cranial fossa famously
involved in sleep and wakefulness, has continually been a topic of scientific advancement …

Melatonin is an endogenous hormone rhythmically produced in the pineal gland under the
control of the suprachiasmatic nucleus (SCN) and the light/dark cycle. This indole plays an …

Neural aging as a progressive loss of function involves central and peripheral postmitotic
neurons and neural stem cells (NSCs). It promotes neurodegeneration, impairs …

The human pineal gland is a neuroendocrine transducer that forms an integral part of the
brain. Through the nocturnally elevated synthesis and release of the neurohormone …