Interaction between a T cell receptor (TCR) and various ligands, ie, anti-TCR antibodies,
superantigens, peptides, or altered peptide ligands in the context of major histocompatibility …

The interaction of the T cell receptor (TCR) with its cognate peptide–major histocompatibility
complex (MHC) on the surface of antigen presenting cells (APCs) is a primary event during T …

Recent data using MHC/peptide tetramers and dimers suggests that the T cell coreceptors,
CD4 and CD8, although important for T cell activation, do not play a direct role in facilitating …

Soluble, dimeric peptide-MHC chimeras were shown to induce Ag-specific T cell anergy in
vitro and in vivo. In this study, we describe a mechanism by which a soluble, dimeric peptide …

Activation of antigen-specific T cell clonesin vivomight be possible by generating soluble
MHC molecules; however, such molecules do not induce effective T cell responses unless …

The functional status (Th1‐versus Th2‐like) of CD4 T cells primed against human collagen
type IV (hCol IV) or a single 30mer peptide from the α2 chain of this molecule is predicted by …

Understanding the regulation of cell surface expression of specific peptide–major
histocompatibility complex (MHC) complexes is hindered by the lack of direct quantitative …

Intrathymic self-peptide–major histocompatibility complex class II (MHC) molecules shape
the T cell repertoire through positive and negative selection of immature CD4+ CD8+ …

The T cell repertoire is shaped by positive and negative selection of thymocytes through the
interaction of α/β-T cell receptors (TCR) with self-peptides bound to self-major …

T cell activation is initiated by recognition of antigenic peptide presented in complex with
MHC molecules on the surface of APCs. The mechanism by which this recognition occurs is …