TRIM22. A multitasking antiviral factor

I Pagani, G Poli, E Vicenzi - Cells, 2021 - mdpi.com
Viral invasion of target cells triggers an immediate intracellular host defense system aimed
at preventing further propagation of the virus. Viral genomes or early products of viral …

TRIM22 inhibits influenza A virus infection by targeting the viral nucleoprotein for degradation

A Di Pietro, A Kajaste-Rudnitski, A Oteiza… - Journal of …, 2013 - Am Soc Microbiol
Tripartite motif (TRIM) protein superfamily members are emerging as important effectors of
the innate immune response against viral infections. In particular, TRIM22 was reported to …

TRIM22: a diverse and dynamic antiviral protein

CJ Hattlmann, JN Kelly, SD Barr - Molecular biology …, 2012 - Wiley Online Library
The tripartite motif (TRIM) family of proteins is an evolutionarily ancient group of proteins with
homologues identified in both invertebrate and vertebrate species. Human TRIM22 is one …

TRIM proteins: another class of viral victims

M Munir - Science signaling, 2010 - science.org
TRIM (tripartite motif) proteins are a family of RING (really interesting new gene) domain–
containing proteins comprising more than 70 human members, with new members still being …

Tripartite Motif 22 (TRIM22) protein restricts herpes simplex virus 1 by epigenetic silencing of viral immediate-early genes

TS Reddi, PE Merkl, SY Lim, NL Letvin… - PLoS …, 2021 - journals.plos.org
Intrinsic resistance is a crucial line of defense against virus infections, and members of the
Tripartite Ring Interaction Motif (TRIM) family of proteins are major players in this system …

Lentiviral effector pathways of TRIM proteins

F Turrini, A Di Pietro, E Vicenzi - DNA and Cell Biology, 2014 - liebertpub.com
The human tripartite motif (TRIM) family, composed of more than 77 members, encompasses
an emerging group of innate antiviral factors. Most TRIM proteins are characterized by being …

The antiviral spectra of TRIM5α orthologues and human TRIM family proteins against lentiviral production

S Ohmine, R Sakuma, T Sakuma, T Thatava… - PLoS …, 2011 - journals.plos.org
Background Rhesus monkey TRIM5α (TRIM5αrh) recognizes the incoming HIV-1 core
through its C-terminal B30. 2 (PRYSPRY) domain and promotes its premature disassembly …

Tripartite-motif proteins and innate immune regulation

FW McNab, R Rajsbaum, JP Stoye… - Current opinion in …, 2011 - Elsevier
The tripartite motif containing (TRIM) proteins are a family of proteins that have been
implicated in many biological processes including cell differentiation, apoptosis …

The interferon-stimulated gene TRIM22: a double-edged sword in HIV-1 infection

E Vicenzi, G Poli - Cytokine & growth factor reviews, 2018 - Elsevier
Infection of target cells by the human immunodeficiency virus type-1 (HIV-1) is hampered by
constitutively expressed host cell proteins preventing or curtailing virus replication and …

Overlapping and distinct molecular determinants dictating the antiviral activities of TRIM56 against flaviviruses and coronavirus

B Liu, NL Li, J Wang, PY Shi, T Wang… - Journal of …, 2014 - Am Soc Microbiol
The tripartite motif-containing (TRIM) proteins have emerged as a new class of host antiviral
restriction factors, with several demonstrating roles in regulating innate antiviral responses …