Background Considerable overlap exists between the risk factors of dementia and cerebral
small vessel disease (SVD). However, studies remain limited to older cohorts wherein …

Background Markers of cerebrovascular disease are common in dementia, and may be
present before dementia onset. However, their clinical relevance in midlife adults at risk of …

Importance It remains unclear if and how associations between cerebral small-vessel
disease and Alzheimer disease (AD) pathology lead to cognitive decline and dementia …

Objective: Cerebral small vessel disease (SVD) is considered the most important vascular
contributor to cognitive decline and dementia, although a causal relation between its MRI …

Background Cerebral small vessel disease (CSVD) comprises a variety of disorders
affecting small arteries and microvessels of the brain, manifesting as white matter …

Background: Cerebral small vessel disease (SVD) is one of the major contributors to
cognitive impairment and dementia. However, data on the incidence and progression of …

Introduction Cerebral small vessel disease is increasingly linked to dementia. Methods We
systematically searched Medline, Embase, and Cochrane databases for prospective …

Alzheimer disease (AD) is the most common cause of dementia. Biological definitions of AD
are limited to the cerebral burden of amyloid β plaques, neurofibrillary pathology, and …

Background: The relationship between cerebral small vessel disease (SVD) and dementia
has been studied without considering white matter (WM) volume, the microstructural integrity …

Background: Cerebral small vessel disease (SVD) and neuropsychiatric symptoms (NPS)
independently increase the risk of cognitive decline. While their co-existence has been …