In this study the similarities and differences between the M2 and M4 subtypes in their
recognition of agonists were explored. A CHO-K1 cell line transfected with the human m2 …

In dissociated cellular preparations of adult rat cortex, M1 and M2 muscarinic receptors were
shown to mediate phosphoinositide metabolism and cAMP inhibition, respectively …

The first publications on genetically defined muscarinic receptor subtypes, which appeared
in October and December, 1986 [l, 21, laid to rest any remaining doubts about the existence …

Pharmacoiogical profiles of the striatai and brainstem M2 recaptors were developed with a
group of selective muscarinic antagonists. The striatal M2 muscarinic receptor was identified …

The coding sequence of the human m2 receptor gene was amplified by polymerase chain
reaction and stably transfected into a murine fibroblast cell line (B82). We have compared …

We previously showed that M1 and M2 muscarinic receptors in dissociated cells of the adult
rat cortex couple to phosphoinositide (Pl) and cyclic AMP (cAMP) metabolism, respectively …

The physiological responses to activation of the m5 muscarinic acetylcholine receptor were
compared with those of m3 and m4 in transformed Chinese hamster ovary cells, using patch …

Affinity estimates were obtained for several muscarinic antagonists against carbachol‐
stimulated [3H]‐inositol phosphates accumulation in Chinese hamster ovary (CHO‐K1) cells …

To compare the proportions of four muscarinic receptors in different rat brain regions, we
used competition curves with four selective antagonists, at 1-[N-methyl-3H] scopolamine …

The cloning and expression of five mammalian muscarinic receptor genes (m1-m5) have
shown that the individual receptor subtypes differ in their functional and ligand-binding …