PURPOSE Whether germline multigene panel testing (MGPT) should be performed in all
individuals with colorectal cancer (CRC) remains uncertain. Therefore, we aimed to …

PURPOSE The early-onset colorectal cancer (EOCRC) burden differs across racial/ethnic
groups, yet the role of germline genetic predisposition in EOCRC disparities remains …

Purpose Universal germline testing in patients with colorectal cancer (CRC) with a
multigene panel can detect various hereditary cancer syndromes. This study was performed …

Background & Aims Hereditary factors play a role in the development of colorectal cancer
(CRC). Identification of germline predisposition can have implications on treatment and …

Importance In 2020, some health insurance plans updated their medical policy to cover
germline genetic testing for all patients diagnosed with colorectal cancer (CRC). Guidelines …

BACKGROUND: Genomic profiling of colorectal cancer aims to identify actionable somatic
mutations but can also discover incidental germline findings. OBJECTIVE: The purpose of …

Colorectal cancer (CRC) is the fourth most frequently diagnosed cancer and 30% of all
cases of CRC are believed to have a familial component and up to one-third of these (10%) …

Introduction The increase in incidence of colorectal cancer in young patients of African
ancestry coupled with increased aggressiveness has warranted investigation of the …

Background & Aims Up to 20% of younger patients (age< 50 years) diagnosed with
colorectal cancer (CRC) have germline mutations in cancer susceptibility genes. Germline …

Purpose Gene–disease associations implicated in hereditary colorectal cancer and
polyposis susceptibility were evaluated using the ClinGen Clinical Validity framework …