Ligand-independent activation of steroid hormone receptors

NL Weigel, Y Zhang - Journal of molecular medicine, 1998 - Springer
In addition to the conventional hormone-dependent regulation of the activity of
steroid/thyroid receptor family members, many studies have shown that there is substantial …

Steroid hormone receptors and their regulation by phosphorylation

NL Weigel - Biochemical Journal, 1996 - portlandpress.com
The steroid/thyroid hormone receptor superfamily of ligand-activated transcription factors
encompasses not only the receptors for steroids, thyroid hormone, retinoids and vitamin D …

Phosphorylation of steroid hormone receptors

E Ortí, JE Bodwell, A Munck - Endocrine Reviews, 1992 - academic.oup.com
I. Introduction M OST members of the steroid hormone receptor superfamily, which includes
glucocorticoid, mineralocorticoid, progestin, estrogen, androgen, 1, 25-dihydroxyvitamin D3 …

Steroid receptor phosphorylation: a key modulator of multiple receptor functions

NL Weigel, NL Moore - Molecular endocrinology, 2007 - academic.oup.com
Steroid receptors are hormone-activated transcription factors, the expression and activities
of which are also highly dependent upon posttranslational modifications including …

Ligand-independent activation of steroid receptors: new roles for old players

B Cenni, D Picard - Trends in Endocrinology & Metabolism, 1999 - cell.com
Steroid receptors are known as ligand-regulated transcription factors, but more and more
evidence indicates that several steroid receptors can be activated in the absence of cognate …

Kinases and protein phosphorylation as regulators of steroid hormone action

NL Weigel, NL Moore - Nuclear receptor signaling, 2007 - journals.sagepub.com
Although the primary signal for the activation of steroid hormone receptors is binding of
hormone, there is increasing evidence that the activities of cell signaling pathways and the …

Role of co-activators and co-repressors in the mechanism of steroid/thyroid receptor action.

H Shibata, TE Spencer, SA Onate… - Recent progress in …, 1997 - europepmc.org
Steroid/thyroid hormone receptors are ligand-dependent transcription factors that regulate
diverse aspects of growth, development, and homeostasis by binding as homodimers or …

Perspective: female steroid hormone action

OM Conneely - Endocrinology, 2001 - academic.oup.com
The steroid hormones estrogen (E) and progesterone (P) play a central role in the regulation
of all aspects of female reproductive activity leading to the establishment and maintenance …

The steroid receptor superfamily: mechanisms of diversity

PJ Fuller - The FASEB journal, 1991 - Wiley Online Library
The steroid receptor superfamily of ligand‐dependent transcription factors is characterized
by marked conservation of both structure and function between the various receptors …

An alternative ligand-independent pathway for activation of steroid receptors

BW O'MALLEY, WT Schrader, S Mani, C Smith… - Proceedings of the 1993 …, 1995 - Elsevier
Publisher Summary Classical steroid hormones such as estrogens, progestins, androgens,
glucocorticoids, and mineralocorticoids act via binding to specific intracellular receptors …