Gut microbiome and metabolome profiling in Framingham heart study reveals cholesterol-metabolizing bacteria

C Li, M Stražar, AMT Mohamed, JA Pacheco… - Cell, 2024 - cell.com
Accumulating evidence suggests that cardiovascular disease (CVD) is associated with an
altered gut microbiome. Our understanding of the underlying mechanisms has been …

Gut microbial associations to plasma metabolites linked to cardiovascular phenotypes and risk: a cross-sectional study

A Kurilshikov, ICL van den Munckhof, L Chen… - Circulation …, 2019 - Am Heart Assoc
Rationale: Altered gut microbial composition has been linked to cardiovascular diseases
(CVDs), but its functional links to host metabolism and immunity in relation to CVD …

[HTML][HTML] Cholesterol metabolism by uncultured human gut bacteria influences host cholesterol level

DJ Kenny, DR Plichta, D Shungin, N Koppel, AB Hall… - Cell host & …, 2020 - cell.com
The human microbiome encodes extensive metabolic capabilities, but our understanding of
the mechanisms linking gut microbes to human metabolism remains limited. Here, we focus …

The gut microbiome across the cardiovascular risk spectrum

FM Prins, V Collij, HE Groot, JR Björk… - European Journal of …, 2024 - academic.oup.com
Aims Despite treatment advancements, cardiovascular disease remains a leading cause of
death worldwide. Identifying new targets is crucial for enhancing preventive and therapeutic …

Microbial impact on cholesterol and bile acid metabolism: current status and future prospects

A Kriaa, M Bourgin, A Potiron, H Mkaouar… - Journal of lipid …, 2019 - ASBMB
Recently, the gut microbiota has emerged as a crucial factor that influences cholesterol
metabolism. Ever since, significant interest has been shown in investigating these host …

Metagenomic analysis of the gut microbiome in atherosclerosis patients identify cross‐cohort microbial signatures and potential therapeutic target

S Liu, W Zhao, X Liu, L Cheng - The FASEB Journal, 2020 - Wiley Online Library
The gut microbiota is associated with cardiovascular diseases, including atherosclerosis.
However, the composition, functional capacity, and metabolites of the gut microbiome about …

Characterization of interactions of dietary cholesterol with the murine and human gut microbiome

HH Le, MT Lee, KR Besler, JMC Comrie… - Nature …, 2022 - nature.com
Consumption of dietary lipids, such as cholesterol, modulates the gut microbiome with
consequences for host health through the production of microbiome-derived metabolites …

An Integrated Metabolomic and Microbiome Analysis Identified Specific Gut Microbiota Associated with Fecal Cholesterol and Coprostanol in Clostridium difficile …

VC Antharam, DC McEwen, TJ Garrett, AT Dossey… - PloS one, 2016 - journals.plos.org
Clostridium difficile infection (CDI) is characterized by dysbiosis of the intestinal microbiota
and a profound derangement in the fecal metabolome. However, the contribution of specific …

Sequence meets function—microbiota and cardiovascular disease

M Kim, MN Huda, BJ Bennett - Cardiovascular research, 2022 - academic.oup.com
The discovery that gut-microbiota plays a profound role in human health has opened a new
avenue of basic and clinical research. Application of ecological approaches where the …

Expanding role of gut microbiota in lipid metabolism

A Ghazalpour, I Cespedes, BJ Bennett… - Current opinion in …, 2016 - journals.lww.com
Recent discoveries have broad implications for elucidating bacterially mediated
pathophysiological mechanisms that alter lipid metabolism and other related metabolic …