Losartan and captopril follow different mechanisms to decrease pressor responses in the pithed rat

H Yokoyama, S Minatoguchi, M Koshiji… - Clinical and …, 1997 - Wiley Online Library
We investigated the effects of losartan and captopril on noradrenaline (NA) release and
vascular reactivity to NA in the pithed rat. 2. The pressor responses to sympathetic nerve …

The Effects of Captopril on the Renin—Angiotensin System and the Sympathetic Nervous System During Sodium Nitroprusside-Induced Hypotension in the Halothane …

SW Stead, BC Bloor - Journal of cardiovascular pharmacology, 1990 - journals.lww.com
Abstract Three groups of New Zealand white rabbits were used to study the effects of
captopril on the renin-angiotensin system and sympathetic nervous system during sodium …

Involvement of nitric oxide, but not prostaglandins, in the vascular sympathoinhibitory effects of losartan in the pithed spontaneously hypertensive rat

C Richer, V Domergue, MP Vincent… - British journal of …, 1996 - Wiley Online Library
1 The aim of this study was to investigate whether nitric oxide (NO) and/or vasodilator
prostaglandins (PGs) are involved in the sympathoinhibitory effects exerted by losartan …

Effects of captopril on vascular noradrenergic transmission in SHR.

DC Eikenburg - Hypertension, 1984 - Am Heart Assoc
The effects of captopril, 3 and 10 mg/kg, on vascular noradrenergic transmission were
examined in vivo in spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto …

Facilitation by procaterol, a β‐adrenoceptor agonist, of noradrenaline release in the pithed rat independently of angiotensin II formation

P Kotsonis, H Majewski - British journal of pharmacology, 1994 - Wiley Online Library
1 The effects of the β2‐adrenoceptor agonist, procaterol, on sympathetic neuroeffector
transmission were studied in the pithed adrenal demedullated rat to determine if generation …

Attenuation of pressor responses to sympathetic stimuli in the rat by enalapril

MP Rechtman, EJN Ishac, ALA Boura… - Clinical and …, 1986 - Wiley Online Library
Intravenous administration to pithed Wistar rats of the angiotensin converting enzyme
inhibitor enalapril (0.1–1.0 mg/kg) lowered the diastolic blood pressure and reduced pressor …

Effect of sodium, deoxycorticosterone and duration of hypertension on pressor responses in rats

RF Bing, GI Russell, JD Swales… - The Journal of …, 1982 - Wiley Online Library
1. Enhanced pressor responsiveness to angiotensin II and noradrenaline has been
demonstrated in the hypertension that follows deoxycorticosterone (DOC) and salt …

Role of a responsive sympathetic nervous system in the chronic hypotensive effects of losartan in normal rats

JP Collister, JW Osborn - Journal of cardiovascular pharmacology, 2005 - journals.lww.com
We have previously demonstrated the chronic hypotensive effects of the AT 1 antagonist
losartan in normotensive, salt-replete rats. We hypothesized that the chronic effects of …

Possible impact of nitric oxide on the antihypertensive effect of captopril and zaprinast

MA Ibrahim, N Satoh, S Ueda - Advances in therapy, 2003 - Springer
The interaction between the renin-angiotensin system and nitric oxide (NO) is undeniable,
but its nature is not fully known. This study investigated the contribution of NO to the acute …

Chronic treatment of the spontaneously hypertensive rat with captopril attenuates responses to noradrenaline in vivo but not in vitro

J Atkinson, M Sonnay, M Sautel, AK Fouda - … -Schmiedeberg's archives of …, 1987 - Springer
We have studied the attenuation by captopril of sympathetic neurotransmission in
spontaneously hypertensive rats. Captopril (4 mg/kg for 15–17 days or 20 mg/kg for 4 days) …