Prodrugs for targeted cancer therapy
Introduction: Prodrugs have been used to improve the selectivity and efficacy of cancer
therapy by targeting unique abnormal markers that are overexpressed by cancer cells and …
therapy by targeting unique abnormal markers that are overexpressed by cancer cells and …
Targeted delivery of chemotherapeutics: tumor-activated prodrug therapy
RVJ Chari - Advanced drug delivery reviews, 1998 - Elsevier
The potential of targeted delivery of chemotherapeutic drugs for the treatment of cancer has
not yet been realized owing to the difficulty of delivering therapeutic concentrations to the …
not yet been realized owing to the difficulty of delivering therapeutic concentrations to the …
Antibody prodrugs for cancer
WM Kavanaugh - Expert opinion on biological therapy, 2020 - Taylor & Francis
Introduction: The toxicity of potent new biological therapies for cancer has limited their utility.
By improving tumor specificity, antibody prodrugs can widen or even create a therapeutic …
By improving tumor specificity, antibody prodrugs can widen or even create a therapeutic …
Prodrugs as drug delivery system in oncology
The use of conventional chemotherapy in the treatment of cancer has been restricted by the
lack of cell specificity, which causes toxicity regarding healthy cells resulting in limiting side …
lack of cell specificity, which causes toxicity regarding healthy cells resulting in limiting side …
Current prodrug design for drug discovery
Prodrugs are inactive compounds which are metabolized either chemically or enzymatically
in a controlled or predictable manner to the parent active drug inside the body. Prodrugs can …
in a controlled or predictable manner to the parent active drug inside the body. Prodrugs can …
Antibody-Drug Conjugates: A promising breakthrough in cancer therapy
S Parit, A Manchare, AD Gholap, P Mundhe… - International Journal of …, 2024 - Elsevier
Antibody-drug conjugates (ADCs) provide effective cancer treatment through the selective
delivery of cytotoxic payloads to the cancer cells. They offer unparalleled precision and …
delivery of cytotoxic payloads to the cancer cells. They offer unparalleled precision and …
Prodrugs for targeted tumor therapies: recent developments in ADEPT, GDEPT and PMT
LF Tietze, K Schmuck - Current pharmaceutical design, 2011 - ingentaconnect.com
The treatment of cancer with common anti-proliferative agents generally suffers from an
insufficient differentiation between normal and malignant cells which results in extensive …
insufficient differentiation between normal and malignant cells which results in extensive …
Prodrugs for improving tumor targetability and efficiency
As the mainstay in the treatment of various cancers for several decades, chemotherapy is
successful but still faces challenges including non-selectivity and high toxicity. Improving the …
successful but still faces challenges including non-selectivity and high toxicity. Improving the …
Prodrug strategy for cancer cell-specific targeting: A recent overview
X Zhang, X Li, Q You, X Zhang - European journal of medicinal chemistry, 2017 - Elsevier
The increasing development of targeted cancer therapy provides extensive possibilities in
clinical trials, and numerous strategies have been explored. The prodrug is one of the most …
clinical trials, and numerous strategies have been explored. The prodrug is one of the most …
Prodrugs: a challenge for the drug development
JB Zawilska, J Wojcieszak, AB Olejniczak - Pharmacological reports, 2013 - Springer
It is estimated that about 10% of the drugs approved worldwide can be classified as
prodrugs. Prodrugs, which have no or poor biological activity, are chemically modified …
prodrugs. Prodrugs, which have no or poor biological activity, are chemically modified …