The increasing occurrence of obesity has become a significant public health concern.
Individuals with obesity have higher prevalence of heart disease, stroke, osteoarthritis …

Ovulatory disorders are the most common clinical feature exhibited among obese women.
Initiation of ovulation physiologically requires a surge of gonadotropin-releasing hormone …

Increasing prevalence in obesity has become a significant public concern. C57BL/6J mice
are prone to diet-induced obesity (DIO) when fed high-fat diet (HFD), and develop chronic …

Infertility associated with obesity is characterized by abnormal hormone release from
reproductive tissues in the hypothalamus, pituitary, and ovary. These tissues maintain …

In middle-aged women, follicular depletion is a critical factor mediating the menopausal
transition; however, all levels of the hypothalamic–pituitary–gonadal (HPG) axis contribute to …

BACKGROUND Because of the substantial energy demands of reproduction, the brain must
temper the fertility of individuals to match nutritional availability. Under-nutrition is associated …

Reproductive function is regulated by the secretion of luteinizing hormone (LH) and follicle-
stimulating hormone from the pituitary and the steroid hormones from the gonads. The …

Background Besides being a risk factor for multiple metabolic disorders, obesity could affect
female reproduction. While increased adiposity is associated with hormonal changes that …

The hypothalamic‐pituitary‐gonadal (HPG) axis undergoes a number of changes
throughout the reproductive life cycle that are responsible for the development, puberty …

BACKGROUND Reproductive function is tightly regulated by nutritional status. Indeed, it has
been well described that undernutrition or obesity can lead to subfertility or infertility in …