TDP-43 is an RNA-binding protein involved in several steps of mRNA metabolism including
transcription, splicing and stability. It is also involved in ALS and FTD, neurodegenerative …

TDP-43 is a soluble, nuclear protein that undergoes cytoplasmic redistribution and
aggregation in the majority of cases of amyotrophic lateral sclerosis and frontotemporal …

The RNA-binding protein TDP-43 is heavily implicated in neurodegenerative disease.
Numerous patient mutations in TARDBP, the gene encoding TDP-43, combined with data …

TDP-43 is a major component of cytoplasmic inclusions observed in neurodegenerative
diseases like frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). To …

TDP-43 (TAR DNA-binding protein 43) is an hnRNP (heterogeneous nuclear
ribonucleoprotein) protein whose role in cellular processes has come to the forefront of …

Transactivation response element (TAR) DNA-binding protein 43 (TDP-43) is the principal
component of ubiquitinated inclusions characteristic of most forms of amyotrophic lateral …

The RNA-binding protein TDP-43 is strongly linked to neurodegeneration. Not only are
mutations in the gene encoding TDP-43 associated with ALS and FTLD, but this protein is …

Transactive response DNA-binding protein 43 (TDP-43) is a predominantly nuclear,
ubiquitously expressed RNA and DNA-binding protein. It recognizes and binds to UG …

TDP-43 is a critical RNA-binding factor associated with pre-mRNA splicing in mammals. Its
expression is tightly autoregulated, with loss of this regulation implicated in human …

TDP-43 proteinopathy, initially associated with ALS and FTD, is also found in 30–60% of
Alzheimer's disease (AD) cases and correlates with worsened cognition and …