Chimeric antigen receptor-engineered NK cells: new weapons of cancer immunotherapy with great potential

X Wang, X Yang, X Yuan, W Wang, Y Wang - Experimental Hematology & …, 2022 - Springer
Chimeric antigen receptor (CAR)-engineered T (CAR-T) cells have obtained prominent
achievement in the clinical immunotherapy of hematological malignant tumors, leading to a …

Chimeric antigen receptor (CAR)-modified NK cells against cancer: Opportunities and challenges

L Wang, M Dou, Q Ma, R Yao, J Liu - International immunopharmacology, 2019 - Elsevier
NK cells may have great potential in tumor immunotherapy because they can kill tumor cells
directly and quickly. Chimeric antigen receptor is a fusion protein composed of extracellular …

Chimeric antigen receptor-engineered natural killer (CAR NK) cells in cancer treatment; recent advances and future prospects

R Elahi, AH Heidary, K Hadiloo… - Stem Cell Reviews and …, 2021 - Springer
Natural Killer (NK) cells are critical members of the innate immunity lymphocytes and have a
critical role in host defense against malignant cells. Adoptive cell therapy (ACT) using …

Chimeric antigen receptor-engineered natural killer cells for cancer immunotherapy

A Yilmaz, H Cui, MA Caligiuri, J Yu - Journal of hematology & oncology, 2020 - Springer
Natural killer (NK) cells are a critical component of the innate immune system. Chimeric
antigen receptors (CARs) re-direct NK cells toward tumor cells carrying corresponding …

Chimeric antigen receptor expressing natural killer cells for the immunotherapy of cancer

RS Mehta, K Rezvani - Frontiers in immunology, 2018 - frontiersin.org
Adoptive cell therapy has emerged as a powerful treatment for advanced cancers resistant
to conventional agents. Most notable are the remarkable responses seen in patients …

CAR-engineered NK cells; a promising therapeutic option for treatment of hematological malignancies

F Marofi, MM Saleh, HS Rahman, W Suksatan… - Stem cell research & …, 2021 - Springer
Adoptive cell therapy has received a great deal of interest in the treatment of advanced
cancers that are resistant to traditional therapy. The tremendous success of chimeric antigen …

CAR-NK cells: A promising cellular immunotherapy for cancer

G Xie, H Dong, Y Liang, JD Ham, R Rizwan, J Chen - EBioMedicine, 2020 - thelancet.com
Natural Killer (NK) cells and CD8+ cytotoxic T cells are two types of immune cells that can
kill target cells through similar cytotoxic mechanisms. With the remarkable success of …

Engineering natural killer cells for cancer immunotherapy

K Rezvani, R Rouce, E Liu, E Shpall - Molecular Therapy, 2017 - cell.com
The past several years have seen tremendous advances in the engineering of immune
effector cells as therapy for cancer. While chimeric antigen receptors (CARs) have been …

Chimeric antigen receptor engineered natural killer cells for cancer therapy

Y Zhang, W Zhou, J Yang, J Yang, W Wang - Experimental Hematology & …, 2023 - Springer
Natural killer (NK) cells, a unique component of the innate immune system, are inherent
killers of stressed and transformed cells. Based on their potent capacity to kill cancer cells …

CAR NK cell therapy in hematologic malignancies and solid tumors; obstacles and strategies to overcome the challenges

ABS Khorasani, AM Yousefi, D Bashash - International …, 2022 - Elsevier
Adoptive cell treatment (ACT) utilizing chimeric antigen receptors (CAR) diverts the
specificity of safe cells against a target-specific antigen and portrays exceptional potential for …