Parkinson's disease (PD) is a neurodegenerative disorder characterized by selective loss of
dopaminergic neurons in the substantia nigra pars compacta (SNpc) region of the midbrain …

The pathogenesis of the second major neurodegenerative disorder, Parkinson's disease
(PD), is closely associated with the dysfunction of potassium (K+) channels. Therefore, PD is …

Potassium (K+) channels are encoded by approximately 80 genes in mammals. They are
expressed in many tissues and have diverse physiological roles. Human K+ channels are …

Within the potassium ion channel family, calcium activated potassium (KCa) channels are
unique in their ability to couple intracellular Ca2+ signals to membrane potential variations …

Potassium (K+) channels, with their diversity, often tissue-defined distribution, and critical
role in controlling cellular excitability, have long held promise of being important drug targets …

Dopamine (DA) releasing midbrain neurons are essential for multiple brain functions, such
as voluntary movement, working memory, emotion and cognition. DA midbrain neurons …

Malfunction in ion channels, due to mutations in genes encoding channel proteins or the
presence of autoantibodies, are increasing being implicated in causing disease conditions …

Potassium channels are tetrameric membrane proteins that selectively conduct K+ across
cellular membranes. With 78 family members, K+ channels make up about half of the …

Parkinson's disease (PD) is a neurodegenerative disorder characterized by the symptoms of
motor deficits and cognitive decline. There are a number of therapeutics available for the …

Parkinson's disease (PD) is a neurological disorder that affects the movement of the human
body. It is primarily characterized by reduced dopamine levels in the brain. The causative …